Quantitative systems toxicology modeling in pharmaceutical research and development: An industry-wide survey and selected case study examples.

Quantitative systems toxicology (QST) models are increasingly being applied for predicting and understanding toxicity liabilities in pharmaceutical research and development. A European Federation of Pharmaceutical Industries and Associations (EFPIA)-wide survey was completed by 15 companies. The results provide insights into the current use of QST models across the industry.

Chemical Recycling of Mixed Polyolefin Post-Consumer Plastic Waste Sorting Residues (MPO323)-Auto-Catalytic Reforming and Decontamination with Pyrolysis Char as an Active Material.

Mixed plastic packaging waste sorting residue (MPO323) was treated by thermal pyrolysis to utilize pyrolysis oil and char. The pyrolysis oil was found to contain aromatic and aliphatic hydrocarbons. The chlorine and bromine contents were as high as 40,000 mg/kg and 200 mg/kg, respectively.

Rodent control strategies and Lassa virus: some unexpected effects in Guinea, West Africa.

The Natal multimammate mouse () is the host of Lassa mammarenavirus, causing Lassa haemorrhagic fever in West Africa. As there is currently no operational vaccine and therapeutic drugs are limited, we explored rodent control as an alternative to prevent Lassa virus spillover in Upper Guinea, where the disease is highly endemic in rural areas. In a seven-year experiment, we distributed rodenticides for 10-30 days once a year and, in the last year, added intensive snap trapping for three months in all the houses of one village.

Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa.

The spread of Lassa virus (LASV) in Guinea, Liberia and Sierra Leone, which together are named the Mano River Union (MRU) area, was examined phylogeographically. To provide a reliable evolutionary scenario, new rodent-derived, whole LASV sequences were included. These were generated by metatranscriptomic next-generation sequencing from rodents sampled between 2003 and 2020 in 21 localities of Guinea and Sierra Leone.

The (Im)perfect Automation Schema: Who Is Trusted More, Automated or Human Decision Support?

Objective: This study's purpose was to better understand the dynamics of trust attitude and behavior in human-agent interaction.

Background: Whereas past research provided evidence for a perfect automation schema, more recent research has provided contradictory evidence.

Method: To disentangle these conflicting findings, we conducted an online experiment using a simulated medical X-ray task.

A validated protocol to UV-inactivate SARS-CoV-2 and herpesvirus-infected cells.

Downstream analysis of virus-infected cell samples, such as reverse transcription polymerase chain reaction (RT PCR) or mass spectrometry, often needs to be performed at lower biosafety levels than their actual cultivation, and thus the samples require inactivation before they can be transferred. Common inactivation methods involve chemical crosslinking with formaldehyde or denaturing samples with strong detergents, such as sodium dodecyl sulfate. However, these protocols destroy the protein quaternary structure and prevent the analysis of protein complexes, albeit through different chemical mechanisms.

Speech Motor Profiles in Primary Progressive Aphasia.

Purpose: Previous research on motor speech disorders (MSDs) in primary progressive aphasia (PPA) has largely focused on patients with the nonfluent/agrammatic variant of PPA (nfvPPA), with few systematic descriptions of MSDs in variants other than nfvPPA. There has also been an emphasis on studying apraxia of speech, whereas less is known about dysarthria or other forms of MSDs. This study aimed to examine the qualitative and quantitative characteristics of MSDs in a prospective sample of individuals with PPA independent of subtype.

Opportunities and Challenges of Disease Progression Modeling in Drug Development - An IQ Perspective.

Disease progression modeling (DPM) represents an important model-informed drug development framework. The scientific communities support the use of DPM to accelerate and increase efficiency in drug development. This article summarizes International Consortium for Innovation & Quality (IQ) in Pharmaceutical Development mediated survey conducted across multiple biopharmaceutical companies on challenges and opportunities for DPM.

Interaction of discourse processing impairments, communicative participation, and verbal executive functions in people with chronic traumatic brain injury.

Introduction: Especially in the chronic phase, individuals with traumatic brain injury (TBI) (IwTBI) may still have impairments at the discourse level, even if these remain undetected by conventional aphasia tests. As a consequence, IwTBI may be impaired in conversational behavior and disadvantaged in their socio-communicative participation. Even though handling discourse is thought to be a basic requirement for participation and quality of life, only a handful of test procedures assessing discourse disorders have been developed so far.

A global and local perspective of interruption frequency in a visual search task.

We investigated the impact of frequency of interruptions in a simulated medical visual search task. Participants ( = 150) performed the visual search task during which they were interrupted by a number-classification task in 25, 50, or 75% of all trials, respectively, reflecting the frequency conditions (i.e.

Stem size prediction in shoulder arthroplasty with preoperative 3D planning.

Introduction: Three-dimensional surgical planning software provides virtual reconstructions of the shoulder with automated joint indices for a preoperative case assessment. The aim of this single center study was to evaluate the concordance between the preoperatively selected humeral components and the final implants used in shoulder arthroplasty.

Methods: 129 cases who had undergone anatomic (n = 16) or reverse shoulder arthroplasty (n = 117) using the same type of uncemented short stem implant and were included for review in this study.

A Quantitative Systems Pharmacology Model of Liver Lipid Metabolism for Investigation of Non-Alcoholic Fatty Liver Disease.

Non-alcoholic fatty liver disease is a metabolic and inflammatory disease that afflicts many people worldwide and presently has few treatment options. To enhance the preclinical to clinical translation and the design of early clinical trials for novel therapeutics, we developed a Quantitative Systems Pharmacology model of human hepatocyte lipid metabolism. The intended application of the model is for simulating anti-steatotic therapies for reversing fatty liver.

Understanding the Impact of Time Pressure and Automation Support in a Visual Search Task.

Objective: To understand the impact of time pressure and automated decision support systems (DSS) in a simulated medical visual search task.

Background: Time pressure usually impairs manual performance in visual search tasks, but DSS support might neutralize this negative effect. Moreover, understanding the impact of time pressure and DSS support seems relevant for many real-world applications of visual search.

Knowing When to Pass: The Effect of AI Reliability in Risky Decision Contexts.

Objective: This study manipulates the presence and reliability of AI recommendations for risky decisions to measure the effect on task performance, behavioral consequences of trust, and deviation from a probability matching collaborative decision-making model.

Background: Although AI decision support improves performance, people tend to underutilize AI recommendations, particularly when outcomes are uncertain. As AI reliability increases, task performance improves, largely due to higher rates of compliance (following action recommendations) and reliance (following no-action recommendations).

Determinants of Laypersons' Trust in Medical Decision Aids: Randomized Controlled Trial.

Background: Symptom checker apps are patient-facing decision support systems aimed at providing advice to laypersons on whether, where, and how to seek health care (disposition advice). Such advice can improve laypersons' self-assessment and ultimately improve medical outcomes. Past research has mainly focused on the accuracy of symptom checker apps' suggestions.

Social Norms and Preventive Behaviors in Japan and Germany During the COVID-19 Pandemic.

Background: According to a recent paper by Gelfand et al., COVID-19 infection and case mortality rates are closely connected to the strength of social norms: "Tighter" cultures that abide by strict social norms are more successful in combating the pandemic than "looser" cultures that are more permissive. However, countries with similar levels of cultural tightness exhibit big differences in mortality rates.

Attitudes Toward Mandatory COVID-19 Vaccination in Germany.

Background: Adequate immunity to COVID-19 apparently cannot be attained in Germany by voluntary vaccination alone, and therefore the introduction of mandatory COVID-19 vaccination is still under consideration. We present findings on the potential acceptance of such a requirement by the German population, and we report on the reasons given for accepting or rejecting it and how these reasons vary according to population subgroup.

Methods: We used representative data from the Socio-Economic Panel for the period January to December 2021.

How Do Master Weightlifters Train? A Transnational Study of Weightlifting Training Practices and Concurrent Training.

(1) Background: The wide range of preparedness, physical fitness, and capabilities of older athletes makes it challenging to recommend general training programs for this cohort ranging from ages 35 to 80 and older. Weightlifting has enjoyed an unprecedented growth in recent years, especially among women. The objectives of this study are to describe age and sex differences in self-reported training regimens and concurrent training for Masters weightlifters and investigate regional differences.

Challenging presumed technological superiority when working with (artificial) colleagues.

Technological advancements are ubiquitously supporting or even replacing humans in all areas of life, bringing the potential for human-technology symbiosis but also novel challenges. To address these challenges, we conducted three experiments in different task contexts ranging from loan assignment over X-Ray evaluation to process industry. Specifically, we investigated the impact of support agent (artificial intelligence, decision support system, or human) and failure experience (one vs.

Vat Photopolymerization of Cemented Carbide Specimen.

Numerous studies show that vat photopolymerization enables near-net-shape printing of ceramics and plastics with complex geometries. In this study, vat photopolymerization was investigated for cemented carbide specimens. Custom-developed photosensitive WC-12 Co (wt%) slurries were used for printing green bodies.

Weightlifting during the COVID-19 Pandemic-A Transnational Study Regarding Motivation, Barriers, and Coping of Master Athletes.

Sport has been heavily impacted by the pandemic for over a year with restrictions and closures of facilities. The main aims of this study are to identify motivation and barriers for an international group of Master weightlifters (ages 35 and up) and analyze age and gender differences in pandemic-related changes to physical activities. A sample of 1051 older athletes, 523 women and 528 men, aged from 35 to 88 years, from Australia, Canada, Europe, and the USA provided responses to an online survey conducted in June 2021.

Experimental Morogoro Virus Infection in Its Natural Host, .

Natural hosts of most arenaviruses are rodents. The human-pathogenic Lassa virus and several non-pathogenic arenaviruses such as Morogoro virus (MORV) share the same host species, namely (). In this study, we investigated the history of infection and virus transmission within the natural host population.