Publications by authors named "Rie Komaki"
Breast Cancer
November 2024
Article Synopsis
- Tailored axillary surgery (TAS) is a new method for selectively removing metastatic lymph nodes in breast cancer patients using a breast biopsy clip and point marker.
- The study involved 30 patients, with 20 undergoing TAS after neoadjuvant chemotherapy, achieving a 90% success rate and 0% false-negative rate in cases also undergoing traditional dissection.
- The findings suggest that TAS is a safe and effective approach for treating breast cancer with lymph node metastases.
Breast Cancer Res Treat
September 2024
Article Synopsis
- Trastuzumab deruxtecan (T-DXd) improves outcomes for patients with HER2-positive metastatic breast cancer, but there's limited guidance on subsequent treatment options.
- In a study involving 29 patients, the median time to treatment failure (mTTF) was 3.5 months across all treatments, with regimens containing trastuzumab showing longer mTTF compared to HER2 tyrosine kinase inhibitors (TKIs).
- The median overall survival (OS) for patients was 14.9 months, indicating a need for more research to determine the most effective treatments following T-DXd therapy.
Article Synopsis
- Advances in breast cancer treatment are focusing on de-escalation therapy, particularly for elderly patients, to minimize harm during treatment.
- An 88-year-old woman with early-stage HER2-positive breast cancer had a remarkable response to a single dose of trastuzumab, leading to a pathological complete response before her scheduled mastectomy.
- This case highlights the potential of trastuzumab monotherapy for certain patients and emphasizes the need for identifying individuals who can benefit from less aggressive treatment options without chemotherapy.
