Efficacy of oral supplemental hydration for the prevention of contrast-induced nephropathy in rats.

Purpose: To compare oral rehydration solution (ORS) with saline infusion for preventing contrast-induced nephropathy (CIN) in a rat model.

Materials And Methods: Adult male Sprague-Dawley rats (310-360 g) received intravenous indomethacin (10 mg/kg), N -nitro-L-arginine methyl ester (10 mg/kg), and iohexol (10 mL/kg) to induce acute contrast-induced renal injury (CIN group); control rats received saline only. For hydration, rats received either continuous infusion (20 mL/kg/h) of saline or three oral doses (20 mL/kg each) of ORS.