A rare case of juvenile acute non-proliferative glomerulonephritis with a 6-year follow-up experience.

Juvenile acute non-proliferative glomerulonephritis (JANG) is a relatively new clinico-pathological entity established in 2000. A PubMed search revealed only two published reports encompassing 14 cases of JANG. It is distinguished from acute post-streptococcal glomerulonephritis by the presence of normal serum complement and the absence of diffuse proliferation of mesangial cells in the glomeruli.

Induction of Zf9 in the kidney following early ischemia/reperfusion.

Background: An improved understanding of the early cell injury mechanisms is critical for effective therapy of acute renal failure (ARF).

Methods: We utilized cDNA microarrays to identify renal genes that are induced very early after renal ischemia in a mouse model, whose protein products might provide novel information regarding the pathogenesis of ARF. The findings were confirmed by downstream mRNA and protein expression studies, as well as knockdown analysis with antisense primers.

Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery.

Background: The scarcity of early biomarkers for acute renal failure has hindered our ability to launch preventive and therapeutic measures for this disorder in a timely manner. We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for ischaemic renal injury after cardiopulmonary bypass.

Methods: We studied 71 children undergoing cardiopulmonary bypass.

Low renal toxicity of lipoplatin compared to cisplatin in animals.

Cisplatin is one of the most widely used and effective chemotherapeutic agents for the treatment of several human malignancies. Although the effectiveness of cisplatin is high, its toxicities justify the demand for improved formulations of this drug. A liposomal formulation of cisplatin, Lipoplatin, was developed in order to reduce the systemic toxicity of cisplatin.