Abnormal Urine Drug Screens in Pregnancy- Opportunity for Laboratory Stewardship.

Background: Clinical testing for drugs of abuse typically involves initial screening followed by confirmatory testing. Due to limited evidence-based guidelines, the healthcare provider makes the decision to confirm abnormal screens based on the clinical context. This two-step approach proved to be inadequate in scenarios like maternal substance abuse and subsequent fetal/ newborn exposure.

Pediatric case of hemoglobin I-high Wycombe variant.

Over 1400 variants of hemoglobin (Hb) have been identified and characterized with phenotypes ranging from clinically silent to severe clinical manifestations in carriers. Different analytical methods have been established to detect Hb variants. Here, we report the first pediatric case of hemoglobin I-High Wycombe [β59(E3) Lys → Glu] variant found in an infant of Mexican-American descent.

Postpartum Glucose Monitoring in Pregnant Women with Gestational Diabetes Mellitus: A Dual Center Experience.

Objective: Gestational diabetes mellitus (GDM) is known to be a predisposing factor in the development of type 2 diabetes mellitus in affected mothers and their offspring. Current guidelines recommend a two-hour postpartum glucose tolerance test (OGTT) in patients with a history of GDM. However, compliance rates for ordering and completion has been reported as suboptimal.

Utility of Cystatin C-based Equation for the Estimation of Glomerular Filtration Rate in a Pediatric Population.

Background: The accurate assessment of kidney function is vital for the early detection of kidney damage. The estimated glomerular filtration rate GFR (eGFR) from serum cystatin C (CysC) and creatinine-based equations are commonly used in clinical practice as an alternative to the invasive measured glomerular filtration rate (mGFR), which is the usually accepted overall best index of kidney function in health and disease. Recently the CKiD under 25 (CkiD U25) equations have been shown to perform well in children and young adults with chronic kidney disease (CKD).

Validation of a whole blood machine learning strategy for distinguishing between bacterial and viral infection in a pediatric hospital setting.

Similar symptoms between viral and bacterial diseases often make diagnosis difficult. This study assessed the clinical performance of the newly cleared whole-blood Bacterial versus Viral Score assay in our pediatric cohort to the previously validated serum assay and emergency department physician diagnosis. This assay shows excellent agreement (R = 0.

ChatGPT-Exploring Its Role in Clinical Chemistry.

Objective: To evaluate the utility of artificial intelligence-powered language models (ChatGPT 3.5 and GPT-4) compared to trainees and clinical chemists in responding to common laboratory questions in the broad area of Clinical Chemistry.

Methods: 35 questions from real-life case scenarios, clinical consultations, and clinical chemistry testing questions were used to evaluate ChatGPT 3.

Do the asymmetric effects of eco-digitalization amidst energy transition make or mar the strides toward environmental sustainability in the USA?

The present era faces adverse effects of the strides recorded in economic advancements of the prior generations thus leading the present generation to growth dilemma. Consequently, there is a conscientious consideration for the ecological effects of economic growth. To resolve the preceding issue, due consideration must be given to harmless growth of which eco-digitalization, green financing, green technology, energy transition, and regularity quality are key determinants.

Neutralizing the surging emissions amidst natural resource dependence, eco-innovation, and green energy in G7 countries: Insights for global environmental sustainability.

The unrelenting surge in global warming in the current era suggests the inevitable need for governments across the globe to embark on policy measures that will help flatten the curve of the surging emissions. Consequently, the concept of carbon neutrality has become a vital policy approach for countries to achieve sustainable development. The present study extends the debates on carbon neutrality by examining the extent to which prominent factors such as natural resource dependence, eco-innovation, and green energy (biofuel and renewable energy) facilitate or hinder strides toward achieving carbon neutral environment in G7 economies.

Probing environmental sustainability pathways in G7 economies: the role of energy transition, technological innovation, and demographic mobility.

Global warming remains the most devastating environmental issue embattling the global economies, with significant contributions emanating from CO emissions. The continued rise in the level of greenhouse gas (GHG) emissions serves as a compelling force which constitutes the core of discussion at the recent COP26 prompting nations to commit to the net-zero emission target. The current research presents the first empirical investigation on the roles of technological advancement, demographic mobility, and energy transition in G7 pathways to environmental sustainability captured by CO emissions per capita (PCCO2) from 2000 to 2019.

The Spread of and Death from Infectious Diseases in Sub-Saharan Africa: Implications for FDI Attraction.

Are "economic bads" of infectious diseases and "economic goods" of foreign direct investment antagonistic to each other? This is the salient question that this research inquiry unravels for 34 African economies from 2000 to 2017. The empirical evidence revealed the following through a generalized method of moments (SGMM) inter alia: First, the mitigating roles of infectious diseases, such as malaria, HIV prevalence rate and AIDS, on global FDI inflows are unconditionally certified from a statistical and economic sense. Second, the diminishing influences of other confounders, such as low per capita GDP, shallow financial development, excruciating inflationary trend, and natural resource rents curse, are empirically endorsed, on the one hand, while the persistent nature of FDI and trade openness as boosting mechanisms for FDI are unambiguously applauded, on the other hand.

The environmental aspects of renewable energy consumption and structural change in Sweden: A new perspective from wavelet-based granger causality approach.

The current paper assessed the time-frequency analysis interrelationship between CO emissions and financial development, economic growth, renewable energy use, structural change, and non-renewable energy use in Sweden. We utilized a quarterly dataset stretching from 1980-2019. In order to unlock these interrelationships, we leverage wavelet tools (wavelet-based Granger causality and wavelet coherence).

On energy transition-led sustainable environment in COP26 era: policy implications from tourism, transportation services, and technological innovations for Gulf countries.

The present generation is witnessing the most devastating effects of global warming far beyond what was evident in the pre-industrial era. To forestall further ecosystem destruction, nations are working assiduously toward achieving sustainable global environment in decades to come, specifically by 2050. This ambitious goal prompts the convergence of countries in the last climate conference tagged COP26 which provides the roadmap to global sustainability.

Beyond COP26: can income level moderate fossil fuels, carbon emissions, and human capital for healthy life expectancy in Africa?

The growing concerns on the need to moderate the unceasing surge in global greenhouse gas (GHG) emissions believed to be detrimental to the environment and wellbeing of the human race have generated concerted efforts from governments and policymakers worldwide. Among many other factors, fossil fuels which remain the most consumed energy resource have been identified as the primary culprit to demeaning life expectancy. To this end, this study probes how income mediates between fossil fuels and carbon emissions to promote life expectancy in selected oil-abundant African economies from 1980 to 2019.

Post-COP26: can energy consumption, resource dependence, and trade openness promote carbon neutrality? Homogeneous and heterogeneous analyses for G20 countries.

The need to halt the pervasive issue of global warming has triggered commitments from policymakers, international organizations, and research pundits with an ambitious goal of neutralizing carbon emissions, forming the core of COP26 in November 2021. Consequently, the carbon neutrality agenda is globally debated in the environment and economic growth literature. Given the preceding narratives, this study examines the tripartite effects of energy consumption, resource dependence, and trade openness on carbon neutrality in G20 economies from 2001 to 2019.

Environmental impacts of income inequality: evidence from G7 economies.

This study probes the environmental consequences of income inequality (INQ) in G7 economies from 1971 to 2015. INQ is captured by four indicators comprising GINI coefficients, Palma ratio, Theil index, and Atkinson index on per capita carbon emission as a proxy for environmental degradation using both fully modified OLS (FM-OLS) and dynamic OLS (D-OLS). The empirical data are subjected to pre-test using cross-sectional dependence (CSD) test and panel unit root and panel cointegration tests.

Disaggregated environmental impacts of non-renewable energy and trade openness in selected G-20 countries: the conditioning role of technological innovation.

This study examines the disaggregated impacts of non-renewable energy (NRE) indicators comprising coal, gas, and fuel, and trade openness (TO) entailing imports and exports on environmental quality proxied by (carbon emission per capita, co2pc) in selected G-20 countries with the conditioning role of technological innovation (ecoi) from 1990 to 2018. The empirical analyses are evaluated using a battery of estimation techniques comprising augmented mean group (AMG), common correlated effect mean group (CCEMG), and mean group (MG), respectively. The following major results are evident from the analyses.

Estimating the impacts of lockdown on Covid-19 cases in Nigeria.

The study examines the extent to which lockdown measures impact on COVID-19 confirmed cases in Nigeria. Six indicators of lockdown entailing retail and recreation, grocery and pharmacy, parks, transit stations, workplaces, and residential, are considered. The empirical evidence is anchored on the negative binomial regression estimator, due to the count nature of the dataset on the daily cases of the virus.

Nonrenewable and renewable energy consumption, trade openness, and environmental quality in G-7 countries: the conditional role of technological progress.

The present study empirically investigates the tripartite impacts of renewable energy (RE), nonrenewable energy (NRE), and trade openness (TO) with the conditioning role of technology on environmental quality (CO emission) for the G-7 countries (Canada, France, Germany, Japan, Italy, USA, and United Kingdom) for the period straddling 1990-2019. The empirical analyses are anchored on a set of estimation procedures including; cross-sectional dependence test, second generation panel unit root test, Westerlund cointegration test, Hausman test, and pooled mean group (PMG). The following results emanate from the findings.

Threshold effects of capital investments on carbon emissions in G20 economies.

Investment in capitals is sacrosanct to launch a country to a greater path of sustainable development. Notwithstanding, its deleterious impacts on environment are equally incontestable. In light of this stark reality, this paper examines the threshold effects of capital investments on carbon emissions in G20 economies over the period, 1992-2014, for which data are available.

Modeling the Political Economy and Multidimensional Factors of COVID-19 Cases in Nigeria.

Both the clinical and epidemiological significance attached to COVID-19 cases by a small, but growing literature on coronavirus are not in any way undermined by the relevance of political economy and multidimensional impacts of other factors on the virus, particularly from country specific stance. In light of the stark reality, this study unravels the political economy and multidimensional factors of COVID-19 cases in Nigeria using the daily data spanning 27th of February through 26th of May, 2020. This paper deploys a variety of count data estimators to estimate the effects of political economy and ethno-religious factors on COVID-19 cases in Nigeria.

Easing of lockdown measures in Nigeria: Implications for the healthcare system.

The year 2020 was ushered in with a historical novel virus (COVID-19) pandemic in a manner that the world has never witnessed before. The human-to-human transmission rates of the virus are not only alarming and worrisome but also, the respiratory dysfunction and unwavering deaths it caused have risen global concerns. We employ the daily situation data on reported cases of COVID-19 to explicate the implications of the lockdown lifting in Nigeria using both qualitative and descriptive statistics.

Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration.

Transthyretin amyloidosis (ATTR) is a progressive life-threatening disease characterized by the deposition of transthyretin (TTR) amyloid fibrils. Several pathogenic variants have been shown to destabilize TTR tetramers, leading to aggregation of misfolded TTR fibrils. However, factors that underlie the differential age of disease onset amongst amyloidogenic TTR variants remain elusive.

Conceptual Development of Immunotherapeutic Approaches to Gastrointestinal Cancer.

Gastrointestinal (GI) cancer is one of the common causes of cancer-related death worldwide. Chemotherapy and/or immunotherapy are the current treatments, but some patients do not derive clinical benefits. Recently, studies from cancer molecular subtyping have revealed that tumor molecular biomarkers may predict the immunotherapeutic response of GI cancer patients.

Contributions of Animal Models to the Mechanisms and Therapies of Transthyretin Amyloidosis.

Transthyretin amyloidosis (ATTR amyloidosis) is a fatal systemic disease caused by amyloid deposits of misfolded transthyretin, leading to familial amyloid polyneuropathy and/or cardiomyopathy, or a rare oculoleptomeningeal amyloidosis. A good model system that mimic the disease phenotype is crucial for the development of drugs and treatments for this devastating degenerative disorder. The present models using fruit flies, worms, rodents, non-human primates and induced pluripotent stem cells have helped researchers understand important disease-related mechanisms and test potential therapeutic options.

Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia.

The primary cilium is a tiny cell protrusion known to transduce key extracellular signals, including those of the sonic hedgehog pathway, which activates Gli transcription factors for various cellular functions. To understand the significance of the Gli2 transcription factor in fibroblasts, we establish a Gli2-knockout NIH3T3 cell line by CRISPR/Cas9 technology. Surprisingly, NIH3T3 fibroblasts lacking Gli2 expression through gene knockout or RNA interference possess longer primary cilia after stimulation of ciliogenesis by serum starvation.