Synopsis of recent research by authors named "Ricky Tirtakusuma"
- Ricky Tirtakusuma's research primarily focuses on the molecular and cellular mechanisms underlying different types of leukemia, particularly B-cell acute lymphoblastic leukemia (B-ALL) and acute myeloid leukemia (AML), exploring how these mechanisms contribute to treatment resistance and disease progression
- Recent findings suggest the presence of fusion transcripts in early progenitor cells in KMT2A-rearranged B-ALL and challenge conventional markers like TIM3 in identifying leukemia-initiating stem cells, indicating a need for revised diagnostic and therapeutic approaches
- Tirtakusuma's work also emphasizes the role of the tumor microenvironment, discovering that human induced pluripotent stem cell-derived niches can reveal essential therapeutic targets for combating niche-mediated treatment resistance in leukemia!
