Early detection of mandible osteoradionecrosis risk in a high comorbidity veteran population.

Objective: Osteoradionecrosis (ORN) of the mandible is a devastating complication of external beam radiation therapy (EBRT) for head and neck squamous cell carcinoma (HNSCC). We sought to ascertain ORN risk in a Veteran HNSCC population treatment with definitive or adjuvant EBRT and followed prospectively.

Study Design: Retrospective analysis of prospective cohort.