Publications by authors named "Rickard K"

Article Synopsis
  • Exacerbations in COPD are serious events that can worsen lung function and impair quality of life, highlighting the need for effective medication to manage them.
  • Ensifentrine is a new drug that works as a dual inhibitor to reduce inflammation and open airways, and the study aimed to evaluate its effectiveness in reducing COPD exacerbation rates.
  • The analysis from two phase 3 trials involving nearly 1,000 patients showed that ensifentrine significantly reduced both the frequency and risk of severe COPD exacerbations compared to a placebo across various patient subgroups.
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Article Synopsis
  • Dyspnea is a key concern in chronic obstructive pulmonary disease (COPD), and the study evaluated the effects of a drug called ensifentrine on this issue using data from Phase 3 trials.
  • In the trials, ensifentrine was tested on 975 patients with COPD, showing significant improvements in dyspnea scores and reduced use of rescue medication after 24 weeks compared to 574 patients on a placebo.
  • The study concluded that ensifentrine effectively alleviated dyspnea for moderate-to-severe COPD patients, although it did not include those already on certain combination therapies.
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Article Synopsis
  • Ensifentrine is a unique inhaled treatment that inhibits PDE3 and PDE4, helping with airway inflammation, bronchodilation, and ciliary function.
  • In Phase 2 studies for COPD patients, it showed significant improvements in lung function, symptoms, and overall health quality, either alone or with other treatments.
  • Currently, ensifentrine is in advanced clinical trials aimed at maintaining treatment for COPD patients, with this review focusing on its non-clinical and Phase 1 and 2 data on effectiveness and safety.
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Article Synopsis
  • Ensifentrine is a new medication that inhibits two enzymes linked to lung function, providing benefits such as bronchodilation and reduced inflammation for patients with chronic obstructive pulmonary disease (COPD).
  • Two large trials (ENHANCE-1 and ENHANCE-2) showed that ensifentrine significantly improved lung function and reduced symptoms and exacerbation rates compared to a placebo, but results varied between the two trials.
  • The studies involved nearly 1,600 patients with moderate to severe COPD, and ensifentrine was well-tolerated, with adverse events being similar to those experienced by patients on placebo.
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Article Synopsis
  • The study aimed to see if a pagan prayer called "The Secret" could help reduce bleeding after heart surgeries that use a tube in the arteries.* -
  • 200 patients were involved in the study, with one group using "The Secret" prayer and another group receiving standard treatment while monitoring for bleeding complications.* -
  • Results showed that there was no real difference in bleeding between the two groups, but most patients thought "The Secret" would help them heal better.*
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We sought to prospectively validate a model to predict the consumption of personal protective equipment in a pediatric emergency department during the COVID-19 pandemic. We developed the Personal Protective Equipment Conservation Strategies Tool, a Monte Carlo simulation model with input parameters defined by members of our emergency department personal protective equipment task force. Inputs include different conservation strategies that reflect dynamic reuse policies.

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Introduction: Hospital datasets are a valuable resource for examining prevalence and outcomes of medical conditions during pregnancy. To enable effective research and health planning, it is important to determine whether variables are reliably captured.

Objective: To examine the reliability of reporting of gestational and pre-existing diabetes, hypertension, thyroid conditions, and morbid obesity in coded hospital records that inform the population-level New South Wales Admitted Patient Data Collection.

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Objective: Hospital data are a useful resource for studying pregnancy complications, including bleeding-related conditions, however, the reliability of these data is unclear. This study aims to examine reliability of reporting of bleeding-related conditions, including anaemia, obstetric haemorrhage and blood disorders, and procedures, such as blood transfusion and hysterectomy, in coded hospital records compared with obstetric data from two large tertiary hospitals in New South Wales.

Results: There were 36,051 births between 2011 and 2015 included in the analysis.

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Article Synopsis
  • Ensifentrine is an inhaled medication that inhibits enzymes linked to inflammation and has been found to improve lung function in COPD patients when used alongside tiotropium over a 4-week period.
  • A clinical study involved 416 patients with moderate-to-severe COPD, showing that ensifentrine significantly enhanced lung function, measured by peak forced expiratory volume (FEV1), in a dose-dependent manner compared to placebo.
  • The study also observed meaningful improvements in health-related quality of life, as measured by the St. George's Respiratory Questionnaire, with no notable difference in adverse events between the ensifentrine and placebo groups.
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Article Synopsis
  • Ensifentrine is an innovative inhaled treatment that targets dual phosphodiesterase (PDE) 3 and 4, showing significant improvements in respiratory symptoms for COPD patients during a four-week clinical trial.
  • The study involved COPD patients aged 40-75, measuring improvements in respiratory symptoms using multiple standardized questionnaires over the trial period, with results indicating all doses of ensifentrine performed better than a placebo.
  • The findings highlight that patients experienced notable early improvements in breathlessness and overall respiratory symptoms, particularly at higher doses of ensifentrine compared to placebo.
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: Fractional exhaled nitric oxide (FeNO) is a valuable tool for assessing Th2 inflammation in children with asthma. Exhalation times of 6 and 10 s meet the current recommendations for assessing FeNO. The 6-s exhalation provides an alternative for 7-10 year olds not able to complete the 10-s exhalation.

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The structure and properties of nanocomposites of poly(ethylene oxide), with Ag and Au nanoparticles, surface modified with a 1:1 (by volume) oleylamine/oleic acid mixture, were investigated via transmission electron microscopy, scanning electron microscopy, thermogravimetric analysis, differential scanning calorimetry (DSC), infrared spectroscopy, dynamic mechanical analysis, and static mechanical testing. Results indicated that there was more oleylamine on Ag nanoparticles but more oleic acid on Au nanoparticles. This difference in surfactant populations on each nanoparticle led to different interfacial interactions with poly(ethylene oxide) and drastically influenced the glass transition temperature of these two nanocomposite systems.

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Objectives: To compare patients who accepted ("acceptors") post acute care services (PAC) with those who were offered services and refused ("refusers") in terms of their sociodemographic and clinical characteristics, quality of life, health-related problems, and unmet needs; and to examine the association between refusing PAC services and the risk for 30- and 60-day readmission.

Study Design: Secondary data analysis from a cross-sectional study.

Methods: Bivariate analysis and logistic regressions were used to examine the association between refusing PAC services and 30- and 60-day readmission.

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Background: Recognition that ascending infection leads to preterm birth has led to a number of studies that have evaluated the treatment of vaginal infections in pregnancy to reduce preterm birth rates. However, the role of candidiasis is relatively unexplored. Our aim was to undertake a systematic review and meta-analysis to assess whether treatment of pregnant women with vulvovaginal candidiasis reduces preterm birth rates and other adverse birth outcomes.

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In a quasi-experimental study, decision support software was installed in three hospitals to study the ability to scale (spread) its use from one hospital on paper to three hospitals as software, and to examine the effect on 30- and 60-day readmissions. The Discharge Decision Support System (D2S2) software analyzes data collected by nurses on admission with a proprietary risk assessment tool, identifies patients in need of post-acute care, and alerts discharge planners. On six intervention units, with a concurrent comparison group of 76 units, we examined the implementation experience and compared readmission outcomes before and after implementation.

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Background: Asthma management in an outpatient setting is best accomplished by clinical evaluation coupled with spirometry and symptom evaluation, but these assessments do not provide information about airway inflammation. Exhaled nitric oxide (fraction of exhaled nitric oxide [FeNO]) measures T-helper cell type 2-mediated airway inflammation and may be a useful adjunct in asthma management.

Objective: To determine whether the use of FeNO in the specialist management of asthma results in more effective and cost-effective treatment decisions.

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Objective: To characterize fractional exhaled nitric oxide (FeNO) levels that may be indicative of Th2-mediated airway inflammation in patients with chronic obstructive pulmonary disease (COPD).

Methods: This single-visit, outpatient study was conducted in 200 patients aged 40 years and older with COPD. All patients underwent spirometry and FeNO testing.

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Objective: One type of test commonly used to assess auditory processing disorders (APD) is the Frequency Pattern Test, in which triads of pure tones of two different frequencies are presented, and participants are required to accurately report the sequence of tones, typically using a verbal response. The test is widely used clinically, but in its current format, is an under-exploited means of addressing some candidate processes, such as temporal ordering and frequency discrimination, which might be affected in APD. Here we describe a computer-based version of an auditory pattern perception test, the BirdSong Game, which was designed to be an engaging research tool for use with school-aged children.

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The differential diagnoses of neck mass may include a wide spectrum of lesions ranging from cysts, inflammatory processes, benign and malignant tumors arising from skin, soft tissue, lymph nodes, endocrine glands, salivary glands to metastatic tumors. In adults, malignant non-thyroid neck masses are often metastatic squamous cell carcinoma. Gynecomastia, presenting as a mass or enlargement in its typical subareolar location is usually a straightforward diagnosis.

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Background: In NSW, around 30% of women experience a caesarean section. Anecdotally, few receive consistent information regarding driving after a caesarean delivery.

Aims: The aims were to determine the information provided to women following caesarean section and by whom it was given, and compare this with women's actual driving behaviour.

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Papillary tumor of the pineal region (PTPR) is a newly recognized distinct entity in the 2007 World Health Organization nomenclature. This tumor is characterized by epithelial-appearing areas with papillary features and more densely cellular areas that often display ependymal-like differentiation. Ultrastructurally, this rare neuroepithelial tumor possesses neuroendocrine, secretory, and ependymal organelles that likely originate from the subcommissural organ (SCO) near the aqueduct of Sylvius.

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Background: Prevention of preterm birth remains one of the most important challenges in maternity care. We propose a randomised trial with: a simple Candida testing protocol that can be easily incorporated into usual antenatal care; a simple, well accepted, treatment intervention; and assessment of outcomes from validated, routinely-collected, computerised databases.

Methods/design: Using a prospective, randomised, open-label, blinded-endpoint (PROBE) study design, we aim to evaluate whether treating women with asymptomatic vaginal candidiasis early in pregnancy is effective in preventing spontaneous preterm birth.

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