Publications by authors named "Rick Rollins"
Article Synopsis
- Accurately identifying and quantifying RNA isoforms in cancer is crucial for understanding genetic variations, analyzing biological pathways, and developing biomarkers.
- The ICGC-TCGA DREAM SMC-RNA challenge was a collaborative project aimed at evaluating methods for RNA isoform quantification and fusion detection using RNA sequencing data, concluding in 2018 with results from 77 fusion detection and 65 isoform quantification submissions.
- The challenge provided a collection of benchmark entries and detailed leaderboards, emphasizing the use of containerized workflows for easy accessibility and reproducibility of the methods developed, with supplementary information on the peer review process.
Protected areas (PAs) can provide important benefits to conservation and to communities. A key factor in the effective delivery of these benefits is the role of governance. There has been a growth in research developing frameworks to evaluate 'good' PA governance, usually drawing on a set of principles that are associated with groups of indicators.
View Article and Find Full Text PDFOxidative damage to DNA is mainly repaired via base excision repair, a pathway that is catalyzed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1). While OGG1 has been implicated in maintaining genomic integrity and preventing tumorigenesis, we report a novel role for OGG1 in altering cellular and whole body energy homeostasis. OGG1-deficient (Ogg1(-/-)) mice have increased adiposity and hepatic steatosis following exposure to a high-fat diet (HFD), compared to wild-type (WT) animals.
View Article and Find Full Text PDFMarine protected areas (MPAs) and zoning plans require an understanding of stakeholders if they are to be successful at achieving social and biological objectives. This study examines recreational boaters in a proposed MPA in British Columbia, Canada, using the recreation opportunity spectrum (ROS) and models of recreation conflict as a basis for investigation. Boaters (n = 543) visiting the region during the summer completed face-to-face surveys.
View Article and Find Full Text PDFZoning and applying Limits of Acceptable Change (LAC) are two promising strategies for managing tourism in Marine Protected Areas (MPAs). Typically, these management strategies require the collection and integration of ecological and socioeconomic data. This problem is illustrated by a case study of Koh Chang National Marine Park, Thailand.
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