Publications by Richika Kotake

Publications by authors named "Richika Kotake"

Mol Biol Cell

December 2015

VAP is a crucial membrane protein in the endoplasmic reticulum that facilitates the transfer of ceramide and cholesterol to the Golgi complex, influencing lipid metabolism.
It interacts with other proteins and is essential for the processing and secretion of specific factors, such as pancreatic adenocarcinoma up-regulated factor, via specialized transport carriers called CARTS.
Depletion of VAP disrupts diacylglycerol levels and CARTS formation, suggesting that the dynamics of ER-Golgi contacts are vital for lipid metabolism and the production of transport carriers.

- Richika Kotake's research primarily focuses on the mechanisms of lipid transfer and protein transport at the endoplasmic reticulum-Golgi interface, emphasizing the role of vesicle-associated membrane protein (VAP) complexes.
- In her 2015 study, she discovered that VAP and its associated proteins are essential for the processing and secretion of the pancreatic adenocarcinoma up-regulated factor, linking VAP function to the transport of proteins to the cell surface via specialized carriers known as CARTS.
- The findings highlighted that depleting VAP leads to a significant reduction in diacylglycerol levels at the trans-Golgi network, ultimately impairing the formation of CARTS and suggesting the critical role of VAP in cellular lipid dynamics and protein trafficking.