Purpose: The genetic characteristics and mismatch repair (MMR) status of the primary tumor and corresponding metastases in colorectal cancer (CRC) are generally considered to be highly concordant. This implies that either the primary or metastatic tumor can be used for testing gene mutation and MMR status. However, whether this is also true for CRC and their ovarian metastases is currently unknown.
View Article and Find Full Text PDFThe reported incidence of synchronous and metachronous ovarian metastases (OM) from colorectal cancer (CRC) is ~3.4%. OM from CRC are often considered sanctuary sites due to their lower sensitivity to systemic treatment.
View Article and Find Full Text PDFBackground And Purpose: In female colorectal cancer patients, a mean proportion of synchronous and/or metachronous ovarian metastases of 3.4% was described. Previous literature showed that young or premenopausal women (≤ 55 years of age) may be more frequently affected.
View Article and Find Full Text PDFProphylactic salpingo-oophorectomy (PSO) can be offered to all patients suffering from colorectal cancer to prevent ovarian metastasis (OM). Arguments to offer PSO are given for discussion: 1. PSO for colorectal cancer is mentioned in various guidelines, 2.
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