Publications by authors named "Richard W Gilles"
Article Synopsis
- Exposure to p38alpha MAPK inhibitors in Beagle dogs leads to acute toxicity characterized by symptoms like decreased activity, diarrhea, and fever, alongside severe lymphoid tissue damage and hemorrhages.
- The earliest noticeable changes include lymphocyte death in gut-associated lymphoid tissue, progressing to inflammation and additional tissue damage in lymph nodes and spleen.
- These toxic effects were specific to dogs, as similar observations were not found in other tested species like mice, rats, or monkeys, highlighting the unique response to p38alpha MAPK inhibition in dogs.
Physiochemical drug properties associated with in vivo toxicological outcomes.
Bioorg Med Chem Lett
September 2008
Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.
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