Plasma membrane Ca-ATPase (PMCA) plays a vital role in maintaining cytosolic calcium concentration ([Ca] ). Given that many diseases have modified PMCA expression and activity, PMCA is an important potential target for therapeutic treatment. This study demonstrates that the non-toxic, naturally-occurring polyphenol resveratrol (RES) induces increases in [Ca] via PMCA inhibition in primary dermal fibroblasts and MDA-MB-231 breast cancer cells.
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