Publications by authors named "Richard Tosti"
Article Synopsis
- The combination of xylazine and illicit fentanyl leads to serious soft tissue injuries, including deep tissue necrosis, due to its impact on tissue toxicity.
- Xylazine, although a non-opioid tranquilizer, enhances the euphoric effects of fentanyl, increasing the risk of abuse and dependence.
- The rise in xylazine-adulterated opioids, particularly in cities like Philadelphia, necessitates a multidisciplinary approach in managing the resulting wounds, emphasizing the roles of hand and reconstructive surgeons.
T cell Ig and mucin domain protein 2 (TIM-2) has been shown to regulate T cell activation in vitro and T cell-mediated disease in vivo. However, it is still not clear whether TIM-2 acts mainly to augment T cell function or to inhibit it. We have directly examined the function of TIM-2 in murine and human T cell lines.
View Article and Find Full Text PDFMany details of the generic pathway for induction of NF-kappaB have been delineated, but it is still not clear how multiple, diverse receptor systems are able to converge on this evolutionarily conserved family of transcription factors. Recent studies have shown that the CARMA1, Bcl10, and MALT1 proteins are critical for coupling the common elements of the NF-kappaB pathway to the T-cell receptor (TCR) and CD28. We previously demonstrated a role for the serine/threonine kinase Akt in CD28-mediated NF-kappaB induction.
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