Cardiovascular Parameters in a Swine Model of Normobaric Hypoxia Treated With 5-Hydroxymethyl-2-Furfural (5-HMF).

Introduction: The consequences of low partial pressure of O include low arterial O saturations (SaO), low blood O content (CaO), elevated mean pulmonary artery pressure (PAP), and decreased O consumption VO. 5-hydroxymethyl-2-furfural (5-HMF) binds to the N-terminal valine of hemoglobin (HgB) and increases its affinity to O. We used an instrumented, sedated swine model to study the effect of 5-HMF on cardiovascular parameters during exposure to acute normobaric hypoxia (NH).