Stability of phenytoin sodium suspensions for the treatment of open wounds.

The objective of this study was to evaluate the stability of two phenytoin sodium suspensions in 0.9% sodium chloride solution for use in noninstitutional settings (where pharmacies are not present) to dispense phenytoin on a daily basis. A generic extended phenytoin sodium (Mylan) and a name brand phenytoin sodium (Dilantin) in suspension form were evaluated.

Possible warfarin failure due to interaction with smokeless tobacco.

Objective: To report a case of possible interaction of smokeless tobacco with warfarin in a patient treated after several thromboembolic events.

Case Summary: A white man with a long history of smokeless tobacco use was unsuccessfully treated with warfarin up to 25-30 mg/day. International normalized ratio (INR) values never stabilized >2.