Publications by authors named "Richard R Carreon"
Anticancer Res
April 2008
Article Synopsis
- Disruption of the 9p21 locus in mesothelioma commonly leads to the loss of p16INK4a and p14ARF, prompting research into the potential of reintroducing p16INK4a using the HIV TAT delivery system to induce cancer cell death.
- A synthetic TATp16INK4a peptide was tested on mesothelioma cells, both in lab settings and in living organisms, showing significant inhibition of Cdk4, cell cycle arrest, and ultimately cell death.
- The study concludes that using TATp16INK4a, or similar small molecule strategies, may provide a promising treatment approach for mesothelioma by effectively inducing apoptosis and altering cell cycle progression.
