Scalp cooling therapy for chemotherapy-induced hair loss in patients with breast or gynecological cancers-an Asian tertiary institution experience.

Purpose: Scalp cooling therapy (SCT) improves chemotherapy-induced alopecia (CIA), but there are few published data about its efficacy in an Asian-predominant population. We report our tertiary institution experience of SCT in patients with breast or gynaecological cancers undergoing chemotherapy.

Methods: The Paxman scalp cooling system was employed for eligible women with breast or gynaecological cancers receiving anthracycline or taxane-based chemotherapy.

A Limb Hypothermia Wearable for Chemotherapy-Induced Peripheral Neuropathy: A Mixed-Methods Approach in Medical Product Development.

Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a common dose-limiting side-effect of taxane-based chemotherapy, causing progressive and often irreversible pain/sensitivity in the hands and feet. Prevention/treatments for CIPN are not well-developed and urgently needed. Limb cryocompression during chemotherapy has demonstrated promising early data of preventing/reducing CIPN severity.

Does Scalp Cooling Have the Same Efficacy in Black Patients Receiving Chemotherapy for Breast Cancer?

Lessons Learned: Despite U.S. Food and Drug Administration approval to reduce alopecia, data on efficacy of scalp cooling in Black patients with cancer are limited by lack of minority representation in prior clinical trials.

Experimental evidence for spatial stabilization of deep-turbulence-induced anisoplanatic blur.

We present field-experiment support for the feasibility of post-detection restoration when imaging through deep turbulence characterized by extreme anisoplanatism. Short-exposure images of point-like and minimally extended objects (MEOs) were collected, viewed through a 5.1-kilometer atmospheric path producing isoplanatic angles roughly 1/15 the camera diffraction-limited angular resolution.

Piston alignment for a segmented-aperture imaging system by using piston-sweep phasing.

This Letter presents a novel method for aligning the piston settings for a segmented-aperture imaging system. By sweeping the piston setting for a reference segment, a stack of images can be acquired that encodes information about the relative piston alignment for all segments in the system. We also demonstrate how a matched-filter processing method can be used to estimate the relative piston settings to align the imaging system at its full resolution.

Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial.

Importance: Chemotherapy may induce alopecia. Although scalp cooling devices have been used to prevent this alopecia, efficacy has not been assessed in a randomized clinical trial.

Objectives: To assess whether a scalp cooling device is effective at reducing chemotherapy-induced alopecia and to assess adverse treatment effects.

Spatial stabilization of deep-turbulence-induced anisoplanatic blur.

We explore the feasibility of post-detection restoration when imaging through deep turbulence characterized by extreme anisoplanatism. A wave-optics code was used to simulate relevant short-exposure point spread functions (PSFs) and their decorrelation as a function of point-source separation was computed. In addition, short-exposure images of minimally extended objects were simulated and shown to retain a central lobe that is clearly narrower than the long-exposure counterpart.

Silhouette estimation.

Silhouettes arise in a variety of imaging scenarios. Pristine silhouettes are often degraded via blurring, detector sampling, and detector noise. We present a maximum a posteriori estimator for the restoration of parameterized facial silhouettes.

Vector transmission matrix for the polarization behavior of light propagation in highly scattering media.

Recently the optical transmission matrix (TM) has been shown to be useful in controlling the propagation of light in highly scattering media. In this paper, we present the vector transmission matrix (VTM) which, unlike the TM, captures both the intensity and polarization transmission property of the scattering medium. We present an experimental technique for measuring the absolute values of the VTM elements which is in contrast to existing techniques whereby the TM elements are measured to within a scaling factor.

Joint estimation of Stokes images and aberrations from phase-diverse polarimetric measurements.

The technique of phase diversity has been used in traditional incoherent imaging systems to jointly estimate an object and optical system aberrations. This paper extends the technique of phase diversity to polarimetric imaging systems. Specifically, we describe penalized-likelihood methods for jointly estimating Stokes images and optical system aberrations from measurements that contain phase diversity.

Overcoming turbulence-induced space-variant blur by using phase-diverse speckle.

Space-variant blur occurs when imaging through volume turbulence over sufficiently large fields of view. Space-variant effects are particularly severe in horizontal-path imaging, slant-path (air-to-ground or ground-to-air) geometries, and ground-based imaging of low-elevation satellites or astronomical objects. In these geometries, the isoplanatic angle can be comparable to or even smaller than the diffraction-limited resolution angle.