Publications by authors named "Richard Paulson"
Article Synopsis
- - The study evaluated trends and outcomes of gestational carrier (GC) pregnancies in the U.S. using data from over 14 million deliveries between 2017 and 2020, finding that the prevalence of GC pregnancies rose by 55% during this period.
- - Among GCs, there was a higher likelihood of complications such as multiple pregnancies, placental abruption, and low-lying placenta, along with increased risks for late-preterm deliveries and postpartum hemorrhage in singleton births compared to non-GCs.
- - While GC pregnancies are relatively rare, the findings indicate they are becoming more common and generally have favorable pre-pregnancy characteristics, but their obstetric outcomes can be mixed, especially regarding certain complications. *
Access to state-of-the-art ART can be viewed as a marker of societal development. The recent Alabama Supreme Court ruling represents a major local setback in the access to state-of-the-art ART. If this isolated local incident becomes a national trend, the USA will lose ground in this emerging area of healthcare, and its citizens will be left with substandard treatment options for the redress of infertility.
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- The study aimed to explore how reproductive endocrinology and infertility specialists manage early pregnancy loss (EPL), focusing on the use of mifepristone.
- A survey of 101 specialists revealed that most prefer medical management for EPL, but only 26.7% prescribe mifepristone due to access issues.
- The research found that those prescribing mifepristone are typically in hospital or university settings, and experience level influences its usage, but factors like age, gender, and prior abortion training do not significantly affect it.
Article Synopsis
- Pre-patterning in embryo development is common in non-mammalian species, but mammals were thought to lack this due to their regulative development, which randomly contributes to the three blastocyst lineages.
- Recent studies show that early blastomeres in mouse and human embryos actually have distinct developmental fates and differences in protein levels, challenging the previous notion of randomness.
- Utilizing advanced proteomics, researchers found that 2-cell embryos contain alpha and beta blastomeres with different protein abundances linked to their developmental potential, with beta blastomeres more likely to produce higher amounts of epiblast cells.
Article Synopsis
- Advancements in assisted reproductive technology have led to a rise in gestational carrier pregnancies, highlighting the need for more research on their perinatal outcomes and associated risks.
- The objective of the study was to analyze maternal characteristics and obstetric outcomes in pregnancies involving gestational carriers.
- A systematic review included six studies analyzing over 28,000 GC pregnancies, revealing higher rates of frozen embryo transfers and comparing various obstetric outcomes with non-GC pregnancies.
Article Synopsis
- The study aimed to find the best letrozole regimen for inducing ovulation in women with polycystic ovary syndrome (PCOS).
- Conducted at a single fertility clinic between 2015 and 2022, it analyzed 189 ovulation induction cycles among 52 women with PCOS.
- Results showed that higher doses and longer regimens (5 mg for 10 days or similar) significantly improved ovulation rates and reduced time to pregnancy compared to the standard regimen.
Article Synopsis
- A study was conducted to analyze obstetric outcomes in pregnant women with congenital uterine anomalies using data from the Nationwide Inpatient Sample between 2016 and 2019.* -
- Out of 50,180 women assessed, the majority had a bicornuate uterus, with 70.6% achieving full-term live births, while 26.8% experienced preterm births.* -
- The findings highlighted that women with uterine didelphys had the highest rates of preterm births, and 65.7% of all patients underwent cesarean sections, with increased risks of severe maternal morbidity associated with septate uteri.*
Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in the body can be traced to the 2-cell stage embryo. However, whether and how such clonal asymmetries arise in the embryo is unclear. Here, we performed prospective lineage tracing of human embryos using live imaging, non-invasive cell labeling, and computational predictions to determine the contribution of each 2-cell stage blastomere to the epiblast (body), hypoblast (yolk sac), and trophectoderm (placenta).
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- The study aimed to evaluate trends and outcomes of pregnancies in women with Turner syndrome in the U.S. using data from hospital deliveries between 2016 and 2020.
- Turner syndrome prevalence among pregnant patients was found to be 7.0 per 100,000 deliveries, with an increase in cases during the study period, suggesting a rising recognition of the condition.
- Pregnant women with Turner syndrome faced higher risks of various complications, such as pregestational hypertension, intrauterine fetal demise, and were more likely to have cesarean deliveries compared to those without the syndrome.
Article Synopsis
- The study investigates the maternal and fetal health outcomes in morbidly obese pregnant women who conceived using assisted reproductive technology (ART), focusing on data from a significant national sample.
- It finds that patients with class III obesity (severe obesity) are at a notably higher risk for complications like hypertensive disorders, diabetes, and adverse neonatal outcomes compared to non-obese patients.
- Overall, the research indicates that severe obesity in pregnancy is linked to an increased likelihood of severe maternal morbidity, highlighting the need for tailored healthcare interventions for this population.
Culture media play an essential role in the success of IVF. Their composition has undergone major modifications over the 45 years since the birth of Louise Brown. Most IVF programmes now rely on commercially produced media, which they buy in small vials, guaranteed to be sterile and non-embryotoxic.
View Article and Find Full Text PDFObjective: To compare the consistency of endometrial receptivity array (ERA) and histologic dating among 3 spatially distinct endometrial samples obtained during a cycle of exogenous estrogen and progesterone.
Design: Prospective blinded study.
Setting: University practice.
Introduction: Since malignancy during pregnancy is uncommon, information regarding contraception selection or sterilization at delivery is limited. The objective of this study was to examine the type of long-acting reversible contraception or surgical sterilization procedure chosen by pregnant patients with malignancy at delivery.
Material And Methods: This cross-sectional study queried the Healthcare Cost and Utilization Project's National Inpatient Sample in the USA.
Our primary objective is to verify or refute a 2013 study by Connolly et al. which showed that in early pregnancy, a gestational sac was visualized 99% of the time on transvaginal ultrasound when the HCG level reached 3510 mIU/mL. Our secondary objective was to make clinical correlations by assessing the relationship between human chorionic gonadotropin (HCG) level in early pregnancy when a gestational sac is not seen and pregnancy outcomes of live birth, spontaneous abortion, and ectopic pregnancy.
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- A study investigated the link between assisted reproductive technology (ART) and various abnormal placentation issues in pregnancies, using data from nearly 15 million deliveries between 2012 and 2015.
- The findings revealed that pregnancies resulting from ART had significantly higher risks for conditions like placenta accreta spectrum (PAS), placenta previa (PP), and vasa previa (VP) compared to those conceived without ART.
- Additionally, pregnancies after ART were more likely to experience multiple abnormal placentation issues simultaneously, highlighting the potential complications associated with ART.
Article Synopsis
- This study investigated how uterine adenomyosis affects obstetric outcomes in women aged 15-54 during hospital deliveries from 2016 to 2019.
- Using a large dataset, researchers found that women with adenomyosis had higher odds of serious placental complications like placenta previa, accreta, and abruption, and were more likely to have premature deliveries and cesarean sections.
- Overall, the findings indicate that uterine adenomyosis is linked to an increased risk of severe complications for both mothers and infants during childbirth.
Objective: To determine the relationship between prior obstetrical history and gestational age at delivery in a twin pregnancy.
Design: Retrospective cohort study using the United States Society for Assisted Reproductive Technology Clinic Outcomes Reporting System database.
Setting: Clinic-based data.