Publications by authors named "Richard P Brown"

Article Synopsis
  • - The community-based social healing (CBSH) model, created by the Ubuntu Centre for Peace, integrates BREATH-BODY-MIND™ practices with collective storytelling and rituals to help individuals facing trauma and mental health challenges improve their mental well-being.
  • - A pilot study with 1889 participants in Rwanda showed that CBSH significantly reduced depression, anxiety, and PTSD while boosting work productivity and decreasing intimate partner violence.
  • - This upcoming cluster randomized controlled trial will assess the effects of CBSH on Ubuntu and mental health across 54 villages, measuring outcomes like depression and resilience using various standardized tools.
View Article and Find Full Text PDF

Long bone ecomorphology has proven effective for paleohabitat reconstructions across a wide range of mammalian clades. Still, there is no comprehensive framework to allow interpretation of long bone morphological variation within and between different monophyletic groups. Here, we investigated the use of humerus morphometry to classify living members of the orders Carnivora and ungulates based on their preferred habitats.

View Article and Find Full Text PDF

Objectives: This pilot study evaluated the feasibility of a live, interactive, synchronous, online, manualized intervention, Breath-Body-Mind Introductory Course (BBM-IC), for medical students. BBM-IC includes breathing, movement, and attention-focus techniques for stress management and better emotion regulation, energy, sleep, and mental focus.

Methods: Medical students attending a 2-h BBM demonstration were invited to participate in the 12-h BBM-IC and weekly 45-min 6-week group practice.

View Article and Find Full Text PDF
Article Synopsis
  • The lizard Teira dugesii shows physical differences between beach and inland environments on Madeira Island, despite some gene flow between populations.
  • Genomic analysis identified 16,378 single nucleotide polymorphisms (SNPs) from 94 lizards, revealing specific SNPs linked to their beach or inland habitats.
  • The study supports the idea that environmental differences drive evolutionary changes in this species, countering the effects of gene flow.
View Article and Find Full Text PDF

Background: During the COVID-19 pandemic, healthcare workers endured prolonged stress affecting their psychological well-being. Objectives: (1) Evaluate the effects of the Breath-Body-Mind Introductory Course (BBMIC) on COVID-related stress among employees of the Regional Integrated Support for Education, Northern Ireland, (2) Reduce the risk of adverse effects from COVID-related stress, and (3) Evaluate the effects of BBMIC on indicators of psychophysiological states and the consistency with hypothesized mechanisms of action.

Methods: In this single group study, a convenience sample of 39 female healthcare workers completed informed consent and baseline measures: Perceived Stress Scale (PSS), Stress Overload Scale-Short (SOS-S), and Exercise-Induced Feelings Inventory (EFI).

View Article and Find Full Text PDF

Populations on the edge of a species' distribution may represent an important source of adaptive diversity, yet these populations tend to be more fragmented and are more likely to be geographically isolated. Lack of genetic exchanges between such populations, due to barriers to animal movement, can not only compromise adaptive potential but also lead to the fixation of deleterious alleles. The south-eastern edge of chimpanzee distribution is particularly fragmented, and conflicting hypotheses have been proposed about population connectivity and viability.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how population divergence occurs in the wall lizard Teira dugesii on Madeira Island due to differences in habitat, specifically contrasting shingle beach and inland environments.
  • Beach lizards were found to be darker and exhibited wider snouts compared to their inland counterparts, indicating distinct morphological traits.
  • Genomic analyses suggest that despite these differences, there is significant gene flow between the populations, supporting the idea that divergence can happen without complete isolation in small island ecosystems.
View Article and Find Full Text PDF

Narwhals and belugas are toothed whales belonging to the Monodontidae. Belugas have a circumpolar Arctic and sub-Artic distribution while narwhals are restricted to the Atlantic Arctic. Their geographical ranges overlap during winter migrations in the Baffin Bay area (Canada/West Greenland) and successful interbreeding may occur.

View Article and Find Full Text PDF

Morphological, functional, and behavioral adaptations of bats are among the most diverse within mammals. A strong association between bat skull morphology and feeding behavior has been suggested previously. However, morphological variation related to other drivers of adaptation, in particular echolocation, remains understudied.

View Article and Find Full Text PDF
Article Synopsis
  • Reintroducing endangered species can be more successful with genetically diverse populations, which enhances their ability to adapt.
  • Mixing individuals from different subspecies can improve survival odds, but excessive diversity can lead to issues like outbreeding depression.
  • In the case of Asiatic wild asses in Israel, a successful breeding core was formed that showed high genetic diversity and no negative effects from hybridization, demonstrating that subspecies mixing can benefit conservation efforts.
View Article and Find Full Text PDF

Genomic divergence was studied in 10 small insular populations of the endangered Balearic Islands lizard (Podarcis lilfordi) using double digest restriction-site associated DNA sequencing. The objectives were to establish levels of divergence among populations, investigate the impact of population size on genetic variability and to evaluate the role of different environmental factors on local adaptation. Analyses of 72,846 SNPs supported a highly differentiated genetic structure, being the populations with the lowest population size (Porros, Foradada and Esclatasang islets) the most divergent, indicative of greater genetic drift.

View Article and Find Full Text PDF

Identification of the role of the MC1R gene has provided major insights into variation in skin pigmentation in several organisms, including humans, but the evolutionary genetics of this variation is less well established. Variation in this gene and its relationship with degree of melanism was analyzed in one of the world's highest-elevation lizards, Phrynocephalus theobaldi from the Qinghai-Tibetan Plateau. Individuals from the low-elevation group were shown to have darker dorsal pigmentation than individuals from a high-elevation group.

View Article and Find Full Text PDF

To determine if a 12-week yoga intervention (YI) was associated with increased gamma aminobutyric acid (GABA) levels and decreased depressive symptoms in participants with major depressive disorder (MDD). : Subjects were randomized to a high-dose group (HDG) of three YIs a week and a low-dose group (LDG) of two YIs a week. Thalamic GABA levels were obtained using magnetic resonance spectroscopy at Scan-1 before randomization.

View Article and Find Full Text PDF
Article Synopsis
  • Evidence suggests yoga may effectively treat major depressive disorder (MDD), with the study aiming to determine the impact of different yoga "doses" on MDD symptoms.
  • A total of 32 participants were assigned to either a high-dose or low-dose group for 12 weeks, and both groups showed significant improvements in various psychological measures.
  • Although the high-dose group had better outcomes, the differences weren't statistically significant, indicating the need for further research, especially as both interventions were effective in reducing depression and anxiety symptoms.
View Article and Find Full Text PDF
Article Synopsis
  • Many species have been identified mainly through their physical traits (morphology) but the use of mtDNA for genetic analysis complicates things, as there's often a conflict between appearance and genetic lineage.
  • Research using genotyping by sequencing (GBS) on lizards in the Qinghai-Tibetan Plateau revealed that genetic differences don't always align with species categorized by morphology, indicating that populations are more distinct geographically rather than based on their physical characteristics.
  • The study highlights the importance of GBS for understanding genetic diversity and cautions against relying solely on morphology for taxonomic classification, as it can lead to incorrect assumptions about species relationships.
View Article and Find Full Text PDF
Article Synopsis
  • Cadmium-containing quantum dots (QDs) are widely used in various technologies, but their potential harmful effects on health and the environment are concerning.
  • This study focuses on how different types of QDs—cadmium-containing (CdSe) and cadmium-free (ZnSe)—interact with lipid membranes (liposomes) and an environmentally relevant bacteria strain (MR-1).
  • The research finds that QD concentration significantly affects membrane stability, with CdSe QDs causing more disruption and bacterial cell death compared to their cadmium-free counterparts, while the presence of a ZnS shell alters the impact of these QDs on membrane integrity.
View Article and Find Full Text PDF

This study advances the chemical research community toward the goal of replacing toxic cadmium-containing quantum dots (QDs) with environmentally benign InP QDs. The InP QD synthesis uniquely combines the previously reported use of InP magic-sized clusters (MSCs) as a single-source precursor for indium and phosphorus to form InP QDs, with zinc incorporation and subsequent ZnS shelling, to form InPZn/ZnS QDs with luminescence properties comparable to those of commonly used cadmium-containing luminescent QDs. The resulting InPZn/ZnS QDs have an emission quantum yield of about 50% across a broad range of emission peak wavelengths and emission peaks averaging 50 nm fwhm.

View Article and Find Full Text PDF
Article Synopsis
  • More loci or partitions in Bayesian divergence time estimation can lead to poor results due to how they affect the prior on the mean substitution rate.
  • A study using mitochondrial data from toad-headed lizards found that increasing partitions made the posterior divergence times too narrow and biased downward.
  • A correction for the mean locus rates produced results comparable to those from a newer program, MCMCtree, suggesting that many BEAST studies may suffer from this issue.
View Article and Find Full Text PDF
Article Synopsis
  • The grass snake and adder are two snake species in Britain that live in the same habitats but have different feeding strategies.
  • Researchers studied their morphologies in Dorset using geometric morphometrics, finding significant sexual dimorphism in head size but not in shape for both species.
  • The study revealed that the grass snake's head shape is influenced by body size, while the adder’s venomous nature may explain its distinct allometric patterns and body shape correlations.
View Article and Find Full Text PDF
Article Synopsis
  • Malic acid carbon dots show superior photoblinking properties compared to traditional dyes and are highly biocompatible, making them ideal for use in advanced microscopy techniques in both fixed and live cells.
  • They do not exhibit “excitation wavelength-dependent” emission, which prompted the development of a quick and efficient method to separate them by particle size using C reversed-phase silica gel column chromatography.
  • This separation technique helps in understanding how different particle sizes affect their optical properties, such as band gap energies and photoluminescence behaviors.
View Article and Find Full Text PDF
Article Synopsis
  • Animals at high altitudes, like toad-headed lizards, must adapt to low oxygen and temperature, offering a unique opportunity to study genetic changes related to adaptation.
  • Researchers analyzed nineteen mitochondrial genomes from Chinese Phrynocephalus lizards, identifying ten positively selected sites linked to mitochondrial Complex I, which is crucial for energy production.
  • These findings suggest that mitochondrial Complex I is under significant environmental selection, implicating it in the evolutionary adaptations of these lizards and highlighting them as models for future molecular evolution research.
View Article and Find Full Text PDF

Objective: A systematic review on S-adenosylmethionine (SAMe) for treatment of neuropsychiatric conditions and comorbid medical conditions.

Data Sources: Searches were conducted in PubMed, EMBASE, PsycINFO, Cochrane Library, CINAHL, and Google Scholar databases between July 15, 2015, and September 28, 2016, by combining search terms for SAMe (s-adenosyl methionine or s-adenosyl-l-methionine) with terms for relevant disease states (major depressive disorder, MDD, depression, perinatal depression, human immunodeficiency virus, HIV, Parkinson's, Alzheimer's, dementia, anxiety, schizophrenia, psychotic, 22q11.2, substance abuse, fibromyalgia, osteoarthritis, hepatitis, or cirrhosis).

View Article and Find Full Text PDF

The Qinghai-Tibetan Plateau (QTP) represents one of the earth's most significant physical features and there is increasing interest in the historical generation of biodiversity within this region. We hypothesized that there should be clear geographically coherent genetic structuring within one of the world's highest altitude lizards, Phrynocephalus theobaldi, due to considerable historical population fragmentation in this environment. This was tested using a major mitochondrial DNA (mtDNA) survey and sequencing of two nuclear markers (AME and RAG-1) from P.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how geographical variation in the lizard Gallotia galloti on Tenerife relates to ecological factors and historical isolation.
  • Analyses of over 276,000 single nucleotide polymorphisms (SNPs) reveal one genetically distinct population linked to historical isolation, while also indicating ecological divergence between xeric (dry) and mesic (moist) habitats.
  • The findings suggest that both historical and ecological factors contribute to genomic diversity, but north-south morphological differences are primarily influenced by ecological divergence.
View Article and Find Full Text PDF