Publications by authors named "Richard Ostenson"
Article Synopsis
- AMACR is a specific marker for prostate cancer, showing higher expression in malignant tissues compared to PSA, and can be detected in the blood of prostate cancer patients using real-time RT-PCR.!* -
- In a study of 163 patients, AMACR was found in a significant number of those with metastatic disease and some with organ-confined disease, indicating its potential to identify circulating tumor cells.!* -
- Preliminary results from urine samples also showed elevated AMACR levels, suggesting that real-time RT-PCR could be a useful tool for detecting and staging prostate cancer.
Aim: To evaluate the utility of a multigene real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay to detect circulating tumor cells in peripheral blood specimens of breast cancer patients during or after treatment.
Method: Using this assay, peripheral blood samples were analyzed for expression levels of mammaglobin and three complementary transcribed breast cancer-specific genes: B305D, gamma-aminobutyrate type A receptor pi subunit (GABA pi; GABRP), and B726P. We examined 172 blood specimens from 82 breast cancer patients during or after therapy for the presence of circulating tumor cells using the multigene real-time RT-PCR assay.