BioNexusSentinel: a visual tool for bioregulatory network and cytohistological RNA-seq genetic expression profiling within the context of multicellular simulation research using ChatGPT-augmented software engineering.

Summary: Motivated by the need to parameterize ongoing multicellular simulation research, this paper documents the culmination of a ChatGPT augmented software engineering cycle resulting in an integrated visual platform for efficient cytohistological RNA-seq and bioregulatory network exploration. As contrasted to other systems and synthetic biology tools, BioNexusSentinel was developed to uniquely combine these features. Reactome served as the primary source of remotely accessible biological models, accessible using BioNexusSentinel's novel search engine and REST API requests.

Novel Ground-Up 3D Multicellular Simulators for Synthetic Biology CAD Integrating Stochastic Gillespie Simulations Benchmarked with Topologically Variable SBML Models.

The elevation of Synthetic Biology from single cells to multicellular simulations would be a significant scale-up. The spatiotemporal behavior of cellular populations has the potential to be prototyped in silico for computer assisted design through ergonomic interfaces. Such a platform would have great practical potential across medicine, industry, research, education and accessible archiving in bioinformatics.

Stability of the K4b² portable metabolic analyser during rest, walking and running.

This study investigated the stability of the measurement of respiratory variables during rest, walking and running using the K4b(2) portable metabolic analyser in ten active males (age 31 ± 11 years; VO₂ peak 42.1 ± 2.6 ml · min(-1) · kg(-1)).