Non-sedative cortical EEG signatures of allopregnanolone and functional comparators.

Neurosteroids that positively modulate GABA receptors are among a growing list of rapidly acting antidepressants, including ketamine and psychedelics. To develop increasingly specific treatments with fewer side effects, we explored the possibility of EEG signatures in mice, which could serve as a cross-species screening tool. There are few studies of the impact of non-sedative doses of rapid antidepressants on EEG in either rodents or humans.

Longitudinal progression of diabetes mellitus in Wolfram syndrome: The Washington University Wolfram Research Clinic experience.

Objective: (1) Describe the progression of diabetes mellitus over time in an observational study of Wolfram syndrome, a rare, genetic, neurodegenerative disorder, which often includes diabetes mellitus and is typically diagnosed during childhood or adolescence. (2) Determine whether C-peptide could be used as a marker of diabetes progression in interventional trials for Wolfram syndrome.

Methods: N = 44 (25F/19M) participants with genetically confirmed Wolfram syndrome attended the Washington University Wolfram Research Clinic annually from 2010 to 2019.

The first puff: forces in smoking initiation among Californians of Korean descent.

This study presents the correlates of initial exposure to cigarettes, variables associated with smoking prevalence and with continued smoking (or not) among adult Californians of Korean descent who have any initial exposure to cigarettes. Among those who have taken a puff, social contingencies contrast those who become current smokers from those who do not. Data were drawn from telephone interviews with adults (N = 2,830) developed from a random sampling of listed persons in California with Korean surnames during 2000-2001.