Research ethics for clinical researchers.

This chapter describes the history of the development of modern research ethics. The governance of research ethics is discussed and varies according to geographical location. However, the guidelines used for research ethics review are very similar across a wide variety of jurisdictions.

Research ethics for clinical researchers.

This paper describes the history of the development of modern research ethics. The governance of research ethics varies according to geographical location. However, the guidelines used for research ethics review are very similar across a wide variety of jurisdictions.

The influences of Ih on temporal summation in hippocampal CA1 pyramidal neurons: a modeling study.

Recent experimental and theoretical studies have found that active dendritic ionic currents can compensate for the effects of electrotonic attenuation. In particular, temporal summation, the percentage increase in peak somatic voltage responses invoked by a synaptic input train, is independent of location of the synaptic input in hippocampal CA1 pyramidal neurons under normal conditions. This independence, known as normalization of temporal summation, is destroyed when the hyperpolarization-activated current, Ih, is blocked [Magee JC (1999a), Nature Neurosci.