Ferric carboxymaltose in the treatment of iron deficiency in pediatric inflammatory bowel disease.

Background: Iron deficiency (ID) with or without anemia is a common complication of pediatric inflammatory bowel disease (IBD), causing significant morbidity. Despite this, ID remains prevalent and undertreated, related in part to questions surrounding optimal formulation and route of administration. Ferric carboxymaltose (FCM) is a recent formulation of intravenous iron, allowing higher doses and rapid infusion times.

Exclusive enteral nutrition induces early clinical, mucosal and transmural remission in paediatric Crohn's disease.

Background And Aims: Exclusive enteral nutrition (EEN) induces clinical and mucosal healing (MH) in Crohn's disease (CD), with MH the best determinant of future outcome. We investigated efficacy of EEN for inducing early clinical, biochemical, mucosal and transmural remission of CD and related early endoscopic response to outcomes at 1 year.

Methods: In a prospective, open label study 34 children (mean 13.