Publications by authors named "Richard Marcel Bruno Moreira Girard"
Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis.
Mariana Galvão Ferrarini Lindice Mitie Nisimura Richard Marcel Bruno Moreira Girard Mayke Bezerra Alencar Mariana Sayuri Ishikawa Fragoso
mSphere
January 2021
Toxoplasmosis, a protozoan infection caused by , is estimated to affect around 2.5 billion people worldwide. Nevertheless, the side effects of drugs combined with the long period of therapy usually result in discontinuation of the treatment.
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- The study investigates the transport of pyruvate in mitochondria, focusing on two subunits, MPC1 and MPC2, which form a complex thought to aid this process.* -
- Researchers attempted to produce MPC proteins but mostly obtained individual subunits instead of the complete complex; however, MPC2 was found to facilitate efficient pyruvate transport when studied in certain environments.* -
- The findings suggest that MPC2 plays a crucial role in pyruvate transport and may be important for understanding conditions related to disrupted pyruvate metabolism.*