Interventions for prevention of neonatal hyperglycemia in very low birth weight infants.

Background: Among very low birth weight (VLBW) infants, early neonatal hyperglycemia is common and is associated with increased risks for death and major morbidities. It is uncertain whether hyperglycemia per se is a cause of adverse clinical outcomes or whether outcomes can be improved by preventing hyperglycemia.

Objectives: To assess effects on clinical outcomes of interventions for preventing hyperglycemia in VLBW neonates receiving full or partial parenteral nutrition.

Interventions for treatment of neonatal hyperglycemia in very low birth weight infants.

Background: Early neonatal hyperglycemia is common among very low birth weight (VLBW) neonates. Increased risks for death and major morbidities have been observed among VLBW neonates who develop hyperglycemia. It is uncertain whether the hyperglycemia per se is a cause of adverse clinical outcomes or whether the incidence of adverse outcomes can be reduced by treatment.

Interventions for prevention of neonatal hyperglycemia in very low birth weight infants.

Background: Among very low birth weight (VLBW) infants, early neonatal hyperglycemia is common and is associated with increased risks for death and major morbidities. It is uncertain whether hyperglycemia per se is a cause of adverse clinical outcomes or whether outcomes can be improved by preventing hyperglycemia.

Objectives: To assess effects on clinical outcomes of interventions for preventing hyperglycemia in VLBW neonates receiving full or partial parenteral nutrition.

Interventions for treatment of neonatal hyperglycemia in very low birth weight infants.

Background: Early neonatal hyperglycemia is common among very low birth weight (VLBW) neonates. Increased risks for death and major morbidities have been observed among VLBW neonates who develop hyperglycemia. It is uncertain whether the hyperglycemia per se is a cause of adverse clinical outcomes or whether the incidence of adverse outcomes can be reduced by treatment.

Selected principles of perinatal-neonatal glucose metabolism.

While the fetus is completely dependent on his/her mother for glucose and other nutrient transfer across the placenta, the adult is completely independent, especially one who is neither pregnant nor diabetic. The neonate is considered to be in a transition between the complete dependence of the fetus and the complete independence of the adult. The heterogeneity that is the hallmark of neonatal glucose metabolism is illustrated by the observation that maintenance of euglycaemia in the sick and/or low-birthweight neonate is especially difficult.

Neonatal glucose metabolism: differential diagnoses, evaluation, and treatment of hypoglycemia.

Hypoglycemia is one of the most common clinical care issues facing the neonatal practitioner. Increasing evidence indicates that neonatal hypoglycemia may have long-term neurologic effects. Care is complicated by the lack of a clearly defined threshold for hypoglycemia in term and preterm infants, however, and by highly variable clinical signs and symptoms.