Our House Is on Fire: Child and Adolescent Psychiatrists in the Era of the Climate Crisis.

The global climate crisis has arrived and is impacting pediatric mental health in the form of children facing more frequent and severe weather-related trauma, experiencing climate-related deprivation and displacement, and experiencing anxiety and grief related to inevitable losses to come. Child and adolescent psychiatrists must respond: we are care providers to individuals and families in distress; we are contributors to the crisis through our own emissions; and we are potential mediators of the crisis, somewhat uniquely, as we work to instill agency and hope.

Open-source automated chemical vapor deposition system for the production of two- dimensional nanomaterials.

The study of two- dimensional (2D) materials is a rapidly growing area within nanomaterials research. However, the high equipment costs, which include the processing systems necessary for creating these materials, can be a barrier to entry for some researchers interested in studying these novel materials. Such process systems include those used for chemical vapor deposition, a preferred method for making these materials.

Ultrasensitive quantification of cardiac troponin I by a Single Molecule Counting method: analytical validation and biological features.

Aim: To evaluate analytical and biological characteristics of the Singulex Clarity® cTnI assay, based upon Single Molecule Counting technology.

Methods: Assay's analytical sensitivity, precision, linearity, hook effect, cross-reactivity or interference by endogenous and exogenous substances, stability, 99th reference percentile [p99th] in EDTA plasma were evaluated in single or multi-site studies.

Results: Detection limit was 0.

Cements in the 21 Century: Challenges, Perspectives, and Opportunities.

In a book published in 1906, Richard Meade outlined the history of portland cement up to that point. Since then there has been great progress in portland cement-based construction materials technologies brought about by advances in the materials science of composites and the development of chemical additives (admixtures) for applications. The resulting functionalities, together with its economy and the sheer abundance of its raw materials, have elevated ordinary portland cement (OPC) concrete to the status of most used synthetic material on Earth.

Multiplex single molecule counting technology used to generate interleukin 4, interleukin 6, and interleukin 10 reference limits.

Detecting biomarkers at pg/ml concentrations or below is, in many situations, critical for quantifying levels in healthy individuals as well as the changes that can occur in the progression of disease states. The ability to detect multiple biomarkers from the same sample allows for better diagnoses, more efficient testing, and lower volumes of sample required. Based on single molecule counting technology, a multiplex instrument was designed and built that is capable of detecting cytokines and other low-abundance proteins at sub-pg/ml quantities in human plasma samples.

Medical risks and benefits of the sweat lodge.

Background: The ancient practice of the sweat lodge is increasingly common as part of healing practice in substance abuse and other programs for American Indians. It is popular outside Indian culture as well. Reported deaths of four whites in sweat-type ceremonies, however, suggest a need for medical caution.

Numerical simulation of the PGNA signal from chlorine diffusion gradients in concrete.

A nondestructive test method for detecting chlorides in concrete has been developed based on prompt gamma neutron activation (PGNA). Its performance has been modeled using a hybrid MCNP/optical ray tracing approach. Since the chlorides often come from de-icing salts applied to the concrete surface, the Cl concentration has a non-linear depth profile which is typically modeled by the erfc function.

Ultrasensitive flow-based immunoassays using single-molecule counting.

Background: Immunoassay (IA) technology has expanded the clinical utility of protein biomarkers, but demands for increased sensitivity, dynamic reporting ranges, and small sample volumes have limited the potential clinical usefulness of many biomarkers. We assessed the performance, including limits of detection (LODs) and the dynamic reporting range, of an IA-based technology, Erenna Immunoassay System, for a series of biomarkers, including cardiac troponin I (cTnI).

Methods: Erenna IAs were used with 10 different and clinically important biomarkers to ascertain the LOD with various sample sizes (10 microL to 200 microL).

Hydration of tricalcium and dicalcium silicate mixtures studied using quasielastic neutron scattering.

Quasielastic neutron scattering was used to study the hydration reaction of tricalcium and dicalcium silicate mixtures by following the fixation of hydrogen into the reaction products, and by applying hydration models to the data. The reaction kinetics were well-described by an Avrami-derived model for the nucleation and growth regime during early hydration times and a diffusion-limited model for later periods. This study showed that the hydration reaction is not a simple linear combination of the reactions for the individual components.

Clinical effects of nitrous oxide conscious sedation in children.

Purpose: This study examined the clinical effects of nitrous oxide conscious sedation on children.

Methods: Fifty-nine healthy children (ages 4 to 13, mean age=7.7 yrs.