Publications by authors named "Richard K McCuller"
Article Synopsis
- The study investigates how interleukin-1β (IL-1β), a pro-inflammatory cytokine, affects the exercise pressor reflex in patients with type 2 diabetes mellitus (T2DM), who also experience peripheral neuropathy.
- Results indicate that blocking IL-1 receptors reduces blood pressure and heart rate responses during exercise in T2DM rats, while activating IL-1 receptors increases these responses in healthy rats.
- The findings suggest that inflammatory cytokines like IL-1β may play a significant role in heightened blood pressure reactions to exercise in individuals with T2DM, highlighting a connection between chronic inflammation and cardiovascular responses.
Patients with type 2 diabetes mellitus (T2DM) have impaired arterial baroreflex function, which may be linked to the co-existence of obesity. However, the role of obesity and its related metabolic impairments on baroreflex dysfunction in T2DM is unknown. This study aimed to investigate the role of visceral fat and adiponectin, the most abundant cytokine produced by adipocytes, on baroreflex dysfunction in T2DM rats.
View Article and Find Full Text PDFStudies in humans and animals have found that type 2 diabetes mellitus (T2DM) exaggerates the blood pressure (BP) response to exercise, which increases the risk of adverse cardiovascular events such as heart attack and stroke. T2DM is a chronic disease that, without appropriate management, progresses in severity as individuals grow older. Thus, it is possible that aging may also exaggerate the BP response to exercise.
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