Early Detection of Human Papillomavirus-Driven Oropharyngeal Cancer Using Serology From the Study of Prevention of Anal Cancer.

This case series examines HPV seropositivity and antibody levels in a cohort of older men who have sex with men.

International Anal Neoplasia Society Guidelines for the Practice of Digital Anal Rectal Examination.

Objective: The aim of the study was to develop recommended techniques and quality assurance metrics for the practice of Digital Anal Rectal Examination (DARE).

Materials And Methods: The International Anal Neoplasia Society undertook a literature review and, using the AGREE II technique, developed guidelines for performing DARE.

Results: A consensus was formed regarding the optimum conditions and characteristics of DARE.

Histological outcomes of anal high-grade cytopredictions.

Background: Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12-month period.

Methods: The Study of the Prevention of Anal Cancer is a 3-year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old.

2016 IANS International Guidelines for Practice Standards in the Detection of Anal Cancer Precursors.

Objectives: To define minimum standards for provision of services and clinical practice in the investigation of anal cancer precursors.

Methods: After initial face to face meetings of experts at the International Papillomavirus meeting in Lisbon, September 17 to 21, 2015, a first version was drafted and sent to key stakeholders. A complete draft was reviewed by the Board of the International Anal Neoplasia Society (IANS) and uploaded to the IANS Web site for all members to provide comments.

Is there a role for the thinprep imaging system in reporting anal cytology?

Background: The ThinPrep Imaging System (TIS) is an accurate time-saving method of reading cervical ThinPrep slides in screening programs. As anal and cervical cytology are morphologically similar, TIS can potentially be used for anal cytology. We assessed the performance of TIS on anal ThinPrep slides from homosexual men in a natural history study of human papillomavirus-related anal abnormalities.