Production and analytic bioinformatics for next-generation DNA sequencing.

The bioinformatics requirements within the clinical environment are very specific, and analytic techniques need to be fit for purpose, robust, and predictable. At the same time, the bewildering amount of information produced during these analyses needs to be carefully managed, used and interpreted correctly. The challenge for clinical laboratories now is to implement production analytical processes that are capable of handling different experimental approaches on current equipment, as well as to incorporate ways for these systems to evolve to take account of developments likely to make impacts in the near future.

Sporadic inclusion body myositis in Japanese is associated with the MHC ancestral haplotype 52.1.

In Caucasians, sporadic inclusion body myositis has been associated with the MHC ancestral haplotypes; HLA-A1, B8, DR3 (8.1AH) and HLA-B35, DR1 (35.2AH).