Cataract Surgery in Patients With Uveitis Treated With Systemic Therapy in the Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study: Risk Factors and Outcomes.

Purpose: To evaluate the rate of, risk factors for, and outcomes of cataract surgery in patients with intermediate, posterior, and panuveitides treated with systemic corticosteroids and immunosuppression.

Design: Cohort study of participants from a randomized clinical trial.

Methods: A multicenter clinical trial with extended follow-up comprised the study setting.

Ultra-low dose external beam radiotherapy for presumed choroidal lymphoma: a case report.

Primary choroidal lymphoma is a rare, slowly progressive intraocular malignancy. Most are low grade B cell lymphomas, often involving tissues adjacent to the choroid such as the subconjunctival space, lacrimal gland or orbit. Ideally, these lesions are biopsied to establish histopathological diagnosis.

Sarcoidosis-related Uveitis: Clinical Presentation, Disease Course, and Rates of Systemic Disease Progression After Uveitis Diagnosis.

Objective: To document the clinical presentation, treatment, and visual outcome of sarcoid uveitis and to determine the timing and potential risk factors of sarcoidosis progression to symptomatic systemic disease from the time of sarcoid uveitis diagnosis.

Design: Retrospective, interventional case series.

Methods: Subjects: Patients with dual diagnoses of uveitis and presumed/biopsy-proven sarcoidosis.

Association of Polymorphisms in MACRO Domain Containing 2 With Thyroid-Associated Orbitopathy.

Purpose: Thyroid-associated orbitopathy (TO) is an autoimmune-mediated orbital inflammation that can lead to disfigurement and blindness. Multiple genetic loci have been associated with Graves' disease, but the genetic basis for TO is largely unknown. This study aimed to identify loci associated with TO in individuals with Graves' disease, using a genome-wide association scan (GWAS) for the first time to our knowledge in TO.

Outcome of Treatment of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial 2-Year Results.

Purpose: To evaluate the 2-year outcomes of uveitic macular edema.

Design: Longitudinal follow-up of a randomized cohort.

Participants: At baseline, 148 eyes of 117 patients enrolled in the Multicenter Uveitis Steroid Treatment (MUST) Trial had macular edema, and 134 eyes of 108 patients completed 2-year follow-up.

The course of uveitis in pregnancy and postpartum.

Aim: To examine the course of non-infectious uveitis during pregnancy.

Methods: This is a retrospective case series. The medical records of 47 subjects with a previous history of non-infectious uveitis pre-dating their pregnancy were reviewed.

Optical coherence tomography evaluation in the Multicenter Uveitis Steroid Treatment (MUST) trial.

Purpose: To describe the evaluation of optical coherence tomography (OCT) scans in the Muliticenter Uveitis Steroid Treatment (MUST) trial and report baseline OCT features of enrolled participants.

Methods: Time-domain OCTs acquired by certified photographers using a standardized scan protocol were evaluated at a reading center. Accuracy of retinal thickness data was confirmed with quality evaluation, and caliper measurement of centerpoint thickness (CPT) was performed when retinal thickness data were unreliable.

The role of toll-like receptor variants in acute anterior uveitis.

Purpose: Acute anterior uveitis (AAU) is the most common form of uveitis; however, while it is presumed to have an immunological basis, the precise underlying etiology remains elusive. Toll-like receptors (TLRs) have a key role in linking innate and adaptive immunity, thereby forming a molecular bridge between microbial triggers and the development of AAU. The purpose of this study was to investigate the role of TLR2 and TLR4 gene polymorphisms in the pathogenesis of AAU.

Acute retinal necrosis: a case series with clinical features and treatment outcomes.

Purpose: To determine clinical features, viral aetiology and treatment outcomes of eyes with acute retinal necrosis (ARN).

Methods: Retrospective, interventional, non-comparative case series.

Results: Twenty-two patients (23 eyes) were identified between 1996 and 2007.

Toxocara canis: egg presence in Melbourne parks and disease incidence in Victoria.

Purpose: Toxocara canis can cause blinding eye disease. This study assessed the presence of T. canis eggs in soil from parks in Melbourne and also the incidence of presumed ocular toxocariasis in Victoria.

Eye signs in systemic disease.

Background: The eye provides clues to the diagnosis of many systemic diseases and many important complications of these diseases occur in the eye.

Objective: To review the important ocular pathology seen in some systemic diseases. The ocular manifestations of a small number of these diseases will be discussed in detail.