Systematic review of oral pharmacotherapeutic options for the management of uterine fibroids.

Background: Uterine fibroids constitute a significant health problem in the United States, affecting upward of 11 million people.

Objective: Characterize the literature regarding the incidence of amenorrhea and reductions in abnormal uterine bleeding and fibroid size and to report on clinically relevant safety outcomes of oral medications that may be used to manage symptomatic uterine fibroids to assist in choice of therapeutic options.

Methods: A literature search was conducted through December 31, 2021, using Embase, MEDLINE, and International Pharmaceutical Abstracts databases.