Publications by authors named "Richard J Kelley"
Clin Pharmacol Drug Dev
July 2014
Article Synopsis
- This study examined how food affects the absorption and distribution of bardoxolone methyl, an antioxidant drug, by testing a 20 mg dose as well as investigating higher doses of 60 and 80 mg.
- The research involved 32 healthy volunteers aged 18-45, with some tested under fasting and others under non-fasting conditions, to assess the drug's pharmacokinetics.
- It found that taking bardoxolone methyl with food didn't change its effectiveness, but larger doses showed less benefit than expected due to saturation in absorption.
