Publications by authors named "Richard J Jenny"
Article Synopsis
- The studies aimed to thoroughly characterize IXINITY (trenonacog alfa), the first recombinant FIX therapeutic, focusing on its purity, structure, and functionality.
- Various techniques, including gel electrophoresis and mass spectrometry, confirmed the product's high purity, significant γ-carboxylation, and proper structural changes when binding to calcium ions.
- The results demonstrated that trenonacog alfa has similar glycosylation patterns and pharmacokinetic performance as plasma-derived FIX, indicating it is a highly effective and consistent therapeutic option.
A critical review of the methods for cleavage of fusion proteins with thrombin and factor Xa.
Protein Expr Purif
September 2003
Expression and purification of proteins in recombinant DNA systems is a powerful and widely used technique. Frequently there is the need to express the protein of interest as a fusion protein or chimeric protein. Fusion protein technology is frequently used to attach a "signal" which can be used for subsequent localization of the protein or a "carrier" which can be used to deliver a "therapeutic" such as a radioactive molecule to a specific site.
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