Feasibility and Effects on Muscle Function of an Exercise Program for Older Adults.

Introduction: Study objective was to determine feasibility and compliance with a 3-month exercise intervention in older adults, and if peripheral quantitative computed tomography muscle measures and jumping mechanography could detect changes in muscle mass and function.

Methods: A parallel group, nonblinded, pilot trial with individuals 70 yr or older randomized to control group of walking-only (WALK) or an intervention group of walking combined with exercises to improve balance and strength (W + EX). Both groups attended similar weekly nutrition education sessions.

Controlled Incorporation of Nitrides into W-Fe-S Clusters.

Incorporation of monatomic 2p ligands into the core of iron-sulfur clusters has been researched since the discovery of interstitial carbide in the FeMo cofactor of Mo-dependent nitrogenase, but has proven to be a synthetic challenge. Herein, two distinct synthetic pathways are rationalized to install nitride ligands into targeted positions of W-Fe-S clusters, generating unprecedented nitride-ligated iron-sulfur clusters, namely [(Tp*) W Fe (μ -N) S L ] (Tp*=tris(3,5-dimethyl-1-pyrazolyl)hydroborate(1-), L=Cl or Br ). Fe Mössbauer study discloses metal oxidation states of W Fe Fe with localized electron distribution, which is analogous to the mid-valent iron centres of FeMo cofactor at resting state.

Ligand metathesis as rational strategy for the synthesis of cubane-type heteroleptic iron-sulfur clusters relevant to the FeMo cofactor.

Molybdenum-dependent nitrogenases catalyze the transformation of dinitrogen into ammonia under ambient conditions. The active site (FeMo cofactor) is the structurally and electronically complex weak-field metal cluster [MoFeSC] built of FeS and MoFeSC portions connected by three sulfur bridges and containing an interstitial carbon atom centered in an Fe trigonal prism. Chemical synthesis of this cluster is a major challenge in biomimetic inorganic chemistry.

Increased Activity in Unstructured Versus Structured Gym Time in an After-School Program.

Background: More than 10 million American youth engage in after-school programs that provide an opportunity to increase physical activity. The purpose of this study was to test the hypothesis that children in unstructured gym time (free) would have greater activity than both structured gym time (structured) and when increased screen time was available.

Methods: Three interventions were compared in a nested design, with each two-week intervention preceded and followed by a two-week control period.

Skin cancer prevention and screening.

Skin cancer is the most common and recognizable of all cancers. The human dermis can turn malignant due to excessive solar exposure and chronic injury, with the influence of genetic risk and inherited pigmentation. Basal cell carcinoma, the most common skin cancer in lighter pigmented individuals, spreads locally, and usually appears pearly and often ulcerative.