Identifying undetected dementia in UK primary care patients: a retrospective case-control study comparing machine-learning and standard epidemiological approaches.

Background: Identifying dementia early in time, using real world data, is a public health challenge. As only two-thirds of people with dementia now ultimately receive a formal diagnosis in United Kingdom health systems and many receive it late in the disease process, there is ample room for improvement. The policy of the UK government and National Health Service (NHS) is to increase rates of timely dementia diagnosis.

Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study.

There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5-10 years earlier in primary care. A case-control study using data from the Clinical Practice Research Datalink.

A cross-sectional randomised study of fracture risk in people with HIV infection in the probono 1 study.

Objective: To determine comparative fracture risk in HIV patients compared with uninfected controls.

Design: A randomised cross-sectional study assessing bone mineral density (BMD), fracture history and risk factors in the 2 groups.

Setting: Hospital Outpatients.