Assessment of fibrosis by transient elastography compared with liver biopsy and morphometry in chronic liver diseases.

Background & Aims: Liver stiffness measurement (LSM) with transient elastography (Fibroscan) can accurately diagnose advanced liver fibrosis, but its performance in early liver fibrosis is less satisfactory. We aimed to study the diagnostic performance of LSM for histologic bridging fibrosis and cirrhosis in various chronic liver diseases and to investigate the effects of liver fibrosis distribution on LSM.

Methods: We prospectively studied consecutive patients with chronic liver diseases undergoing liver biopsy and transient elastography examinations.