Faecal calprotectin for differentiating between irritable bowel syndrome and inflammatory bowel disease: a useful screen in daily gastroenterology practice.

Objective: To determine the best faecal calprotectin (FCP) cut-off level for differentiating between irritable bowel syndrome (IBS) and organic disease, particularly inflammatory bowel disease (IBD), in patients presenting with chronic diarrhoea.

Design: Retrospective analysis of patients who had colonoscopy, histology and FCP completed within 2 months.

Setting: District general hospital.

Self-assembly of a bis(adeninyl)-Cu(I) complex: a cationic nucleobase duplex mimic.

The tetrahedral bis(adeninyl)-Cu(I) complex, , self-associates in polar solvent through complementary hydrogen-bonding interactions and appears to mimic the natural assembly of duplex DNA.