Publications by authors named "Richard E Evenhuis"
Background: The decreased perfusion of osteosarcoma in dynamic contrast-enhanced (DCE) MRI, reflecting a good histological response to neoadjuvant chemotherapy, has been described.
Purpose: In this study, we aim to explore the potential of the relative wash-in rate as a prognostic factor for event-free survival (EFS).
Methods: Skeletal high-grade osteosarcoma patients, treated in two tertiary referral centers between 2005 and 2022, were retrospectively included.
Aim of this explorative pilot study was to evaluate the capability of an electronic nose (aeoNose, the eNose Company) to classify healthy individuals and patients with chondrosarcoma, based on their volatile organic compound profiles in exhaled breath. Fifty-seven patients (25 healthy controls, 24 chondrosarcoma and 8 different benign lesions) were included in the study from 2018 to 2023. An artificial neural network was used as classifier.
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- The article was updated on July 17, 2024, to correct authorship and acknowledge the affiliation of a new author, Edwin F. Dierselhuis, MD, PhD, with the Department of Orthopaedic Surgery in Nijmegen, Netherlands.
- The study investigates mid-term complications and revision rates of periacetabular tumor reconstructions using the LUMiC prosthesis in patients who underwent specific types of hemipelvectomy from 2008 to 2022.
- Data from 166 patients showed a significant reoperation rate, with 49% of patients undergoing additional surgeries for complications, indicating notable challenges in mid-term outcomes.
Background: Osteosarcoma and Ewing sarcoma patients face a significant risk of cardiotoxicity as defined by left ventricular dysfunction and heart failure (HF).
Objectives: This study sought to evaluate the association between age at sarcoma diagnosis and incident HF.
Methods: A retrospective cohort study was performed at the largest sarcoma center in the Netherlands among patients with an osteosarcoma or Ewing sarcoma.
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- This study investigates the changes in serum metal ion levels following hip or knee megaprosthesis reconstruction and links these changes to adverse health effects.
- Fourteen patients were monitored, with blood samples taken pre- and post-surgery to measure aluminum, chromium, cobalt, and silver ion levels.
- Postoperative findings revealed substantial increases in metal ion concentrations, particularly in chromium, silver, and cobalt, although only one patient experienced a direct adverse effect related to these elevations (argyria).*
Background: Patients with osteosarcoma (OS) and Ewing sarcoma (ES) are considered to have a high venous thromboembolism (VTE) risk, although the exact incidence and prognostic impact are under-researched in general as well as in relevant age groups.
Aims: To study the impact of VTE and major bleeding (MB) in OS and ES patients, subdivided in children, Adolescents Young Adults (AYAs; aged 18-39) and older adults.
Methods: Retrospective single-center chart review in 519 OS and 165 ES patients treated between 1980 and 2018.
Age is a known prognostic factor for many sarcoma subtypes, however in the literature there are limited data on the different risk profiles of different age groups for osteosarcoma survival. This study aims to provide an overview of survival in patients with high-grade osteosarcoma in different age groups and prognostic variables for survival and local control among the entire cohort. In this single center retrospective cohort study, 402 patients with skeletal high-grade osteosarcoma were diagnosed and treated with curative intent between 1978 and 2017 at the Leiden University Medical Center (LUMC).
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