Low Gonadotropin Dosage Reduces Aneuploidy in Human Preimplantation Embryos: First Clinical Study in a UAE Population.

Type Of Study: Retrospective analysis of embryo aneuploidy in patients undergoing in vitro fertilization (IVF) cycles.

Aim: To evaluate factors that might affect the incidence of embryo aneuploidy during IVF cycles.

Methods: Three hundred twelve IVF cases were included in the present study.

Validation of Next-Generation Sequencer for 24-Chromosome Aneuploidy Screening in Human Embryos.

Background: Next-Generation Sequencing (NGS) is the latest approach for preimplantation genetic diagnoses (PGD).

Aim: The purpose of this study was to standardize and validate an NGS method for comprehensive chromosome screening and to investigate its applicability to PGD.

Methods: Embryo biopsy, whole-genome amplification, array comparative genomic hybridization (aCGH), and semiconductor sequencing were employed.