Neurocircuits underlying cognition-emotion interaction in a social decision making context.

Decision making (DM) in the context of others often entails complex cognition-emotion interaction. While the literature suggests that the ventromedial prefrontal cortex (vmPFC), striatum, and amygdala are involved in valuation-based DM and hippocampus in context processing, how these neural mechanisms subserve the integration of cognitive and emotional values in a social context remains unclear. In this study we addressed this gap by systematically manipulating cognition-emotion interaction in a social DM context, when the participants played a card game with a hypothetical opponent in a behavioral study (n=73) and a functional magnetic-resonance-imaging study (n=16).

Nanostructured Pt(NH(3))(4)Cl(2)/SiO(2) for nanomedicine: catalytic degradation of DNA in cancer cells.

In vivo suppression of glioblastoma multiforme (GBM) in Wistar rats using silica-shelled biocatalytic Pt(NH(3))(4)Cl(2) nanoparticles is reported. These nanoparticles were synthesized by a sol-gel technique and characterized by SEM and HRTEM imaging. We confirmed morphological uniformity (30 nm) and surface acidity of the nanoparticles, respectively, by TEM imaging and FTIR spectral analysis.

The effect of water on particle size, porosity and the rate of drug release from implanted titania reservoirs.

The implantation of controlled drug release devices represents a new strategy in the treatment of neurodegenerative disorders. Sol-gel titania implants filled with valproic acid, have been used for this purpose to treat induced epilepsy in rats. The kinetics of the drug release depend on: (a) porosity, (b) chemical interactions between valproic acid and surface hydroxyl groups of titania, (c) particle size, and (d) particle size agglomerates.