Predicting individual differences in response to sleep loss: application of current techniques.

Background: Fatigue's negative impact on safety represents one of the top threats to military transportation. Biomathematical models have been developed to predict the response to fatigue; however, current models do not take into account stable individual differences in fatigue susceptibility. Readiness Screening Tools (RSTs) can capture individual differences in fatigue response, but cannot predict performance long-term.

A single dose of armodafinil significantly promotes vigilance 11 hours post-dose.

Objective: This study was conducted to test the ability of armodafinil to promote vigilance among air traffic control operators 8 to 11 hours post-dose.

Methods: Forty-eight U.S.