Factors Influencing Response to Aflibercept in Diabetic Macular Oedema Patients in a Diverse North West London Population: A Real-World Study.

Background: Diabetic macular oedema (DMO) is the leading cause of sight impairment in working age populations in developed countries. Current first line treatment for centre-involving DMO involves intravitreal anti-VEGF but treatment response can be variable. In this retrospective, real world, multi-centre cohort study, we aim to identify ocular and systemic characteristics that correlate with anatomical and functional outcomes for treatment-naive DMO patients treated with intravitreal aflibercept.

Postoperative glaucoma following infantile cataract surgery: an individual patient data meta-analysis.

Importance: Infantile cataract surgery bears a significant risk for postoperative glaucoma, and no consensus exists on factors that may reduce this risk.

Objective: To assess the effect of primary intraocular lens implantation and timing of surgery on the incidence of postoperative glaucoma.

Data Sources: We searched multiple databases to July 14, 2013, to identify studies with eligible patients, including PubMed, MEDLINE, EMBASE, ISI Web of Science, Scopus, Central, Google Scholar, Intute, and Tripdata.

Non-invasive anterior segment and posterior segment optical coherence tomography and phenotypic characterization of aniridia.

Objective: To determine the value of optical coherence tomography (OCT) as a diagnostic tool in the critical evaluation of phenotypic variability seen in an aniridia family with a novel PAX6 mutation.

Design: Genetic and observational family study.

Participants: Three-generation family segregating autosomal dominant aniridia.