Publications by authors named "Richard C Raabe"
Article Synopsis
- This study investigates the genetic factors linked to alcohol dependence by conducting a genomewide association study with a sample of related cases and population controls.
- Researchers found potential associations with genes COL6A3, KLF12, RYR3, and LOC339975; however, these were not consistently replicated in larger populations.
- The experiment using model organisms shows that these genes may affect behaviors related to alcohol response, pointing to their possible role in human alcohol dependence, despite some findings not being statistically significant.
Alcohol use disorders are a significant public health concern, for which there are few effective treatment strategies. One difficulty that has delayed the development of more effective treatments is the relative lack of understanding of the molecular underpinnings of the effects of ethanol on behavior. The nematode, Caenorhabditis elegans (C.
View Article and Find Full Text PDFAlcohol addiction is a widespread societal problem, for which there are few treatments. There are significant genetic and environmental influences on abuse liability, and understanding these factors will be important for the identification of susceptible individuals and the development of effective pharmacotherapies. In humans, the level of response to alcohol is strongly predictive of subsequent alcohol abuse.
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