Publications by authors named "Richard Biegon"
Over the past few years, a number of studies have revealed that a significant number of men with prostate cancer had genetic defects in the DNA damage repair gene response and mismatch repair genes. Certain of these modifications, notably gene alterations known as homologous recombination (HRR) genes; , , , , and genes for DNA mismatch repair (MMR); , , , and are connected to a higher risk of prostate cancer and more severe types of the disease. The DNA damage repair (DDR) is essential for constructing and diversifying the antigen receptor genes required for T and B cell development.
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- A study in rural Kenya found that 41% of asymptomatic residents had antibodies against the SARS-CoV-2 spike protein, and 82.5% exhibited T cell responses to multiple viral proteins, indicating some level of immunity despite not showing symptoms.
- The immune response profile in Kenyan participants was distinct from those in Europe and Asia, exhibiting strong reactions to accessory proteins rather than structural ones and a unique cytokine balance (higher IL-10 to IFN-γ ratio).
- These findings suggest that current methods of measuring COVID-19 prevalence may underestimate infections in asymptomatic populations, and highlight the potential influence of environmental factors on immune responses in Africa.