Publications by authors named "Richard B Devereux"
Article Synopsis
- Uranium, a toxic element found in U.S. drinking water, was studied to see if its levels in urine are linked to heart health in American Indian young adults.
- The study analyzed data from over 1,300 participants, measuring urinary uranium and assessing heart function through echocardiography over several years.
- Results showed higher urinary uranium levels were associated with negative changes in heart structure and function, indicating a possible risk for cardiovascular issues that merits further research.
BACKGROUNDLeft ventricular hypertrophy (LVH) and dyslipidemia are strong, independent predictors for cardiovascular disease, but their relationship is less well studied. A longitudinal lipidomic profiling of left ventricular mass (LVM) and LVH is still lacking.METHODSUsing liquid chromatography-mass spectrometry (LC-MS), we repeatedly measured 1,542 lipids from 1,755 unique American Indians attending 2 exams (mean, 5 years apart).
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- A study was conducted on heart failure (HF) risk factors among American Indian communities, revealing a lack of existing research in this area despite high diabetes and cardiovascular issues.
- The study analyzed data from 3,059 participants, identifying key predictors of HF over time, including age, smoking, kidney damage, and history of heart attacks, with strong predictive performance indicated.
- The findings highlight that diabetes control and kidney damage indicators are significant in determining HF risks, which could help improve risk prediction and management in these communities.
Article Synopsis
- A study in Port-au-Prince, Haiti, found that 14.7% of adults have cardiovascular disease (CVD), with prevalent conditions including heart failure (11.9%) and stroke (2.4%).
- The research involved gathering diverse health data from over 3,000 participants and identified key risk factors such as hypertension and obesity linked to heart failure.
- The findings reveal a significant presence of early-onset heart failure in Haiti, highlighting the need for tailored health policies in low- and middle-income countries based on local epidemiological data.
The generalized estimating equations method (GEE) is commonly applied to analyze data obtained from family studies. GEE is well known for its robustness on misspecification of correlation structure. However, the unbalanced distribution of family sizes and complicated genetic relatedness structure within each family may challenge GEE performance.
View Article and Find Full Text PDFBackground: Although many studies on the association between dyslipidemia and cardiovascular disease (CVD) exist in older adults, data on the association among adolescents and young adults living with disproportionate burden of cardiometabolic disorders are scarce.
Methods And Results: The SHFS (Strong Heart Family Study) is a multicenter, family-based, prospective cohort study of CVD in an American Indian populations, including 12 communities in central Arizona, southwestern Oklahoma, and the Dakotas. We evaluated SHFS participants, who were 15 to 39 years old at the baseline examination in 2001 to 2003 (n=1440).
[Summary: International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes].
Arch Cardiol Mex
February 2024
Article Synopsis
- - This document serves as an evidence-based guideline for naming and classifying congenital bicuspid aortic valve and its associated conditions, aimed at a wide range of medical professionals.
- - It is designed for use by pediatricians, cardiologists, surgeons, and researchers, ensuring clarity across various healthcare fields.
- - The consensus is subject to updates as new research and key findings emerge, highlighting its dynamic nature in adapting to evolving medical knowledge.
Background: Chronic lead exposure is associated with both subclinical and clinical cardiovascular disease. We evaluated whether declines in blood lead were associated with changes in systolic and diastolic blood pressure in adult American Indian participants from the SHFS (Strong Heart Family Study).
Methods And Results: Lead in whole blood was measured in 285 SHFS participants in 1997 to 1999 and 2006 to 2009.
Background: Biomechanical effects of transcatheter (TAVR) versus surgical (SAVR) aortic valve interventions on the distal aorta have not been studied. This study utilized global circumferential strain (GCS) to assess post-procedural biomechanics changes in the descending aorta after TAVR versus SAVR.
Methods: Patients undergoing TAVR or SAVR for aortic stenosis were included.
Background: With preventive aortic grafting decreasing the incidence of type A dissections in Marfan syndrome (MFS), most dissections are now type B, for which risk factors remain largely uncertain.
Objectives: We explored the determinants of type B dissection risk in a large, single-center MFS registry.
Methods: Demographic and anthropometric features, cardiovascular disease, and surgical history were compared in patients with MFS with and without type B dissection.
More than 90 % of patients developing heart failure (HF) have hypertension. The most frequent concomitant conditions are type-2 diabetes mellitus, obesity, atrial fibrillation, and coronary disease. HF outcome research focuses on decreasing mortality and preventing hospitalization for worsening HF syndrome.
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- * A study analyzed 65 subjects and found that a VTI-h threshold of ≥15.5 can help discriminate between individuals at risk for cardiovascular issues, with a sensitivity of 70% and specificity of 76%.
- * Age influences cardiovascular event rates, with VTI-h ≥15.5 showing a stronger correlation to events in high-risk variants among individuals under 40, indicating that genetic factors may modify the relationship between tortuosity and
Background And Aims: Dyslipidemia is an independent risk factor for atherosclerosis and atherosclerotic cardiovascular disease (ASCVD). To date, a comprehensive assessment of individual lipid species associated with atherosclerosis is lacking in large-scale epidemiological studies, especially in a longitudinal setting. We investigated the association of circulating lipid species and its longitudinal changes with carotid atherosclerosis.
View Article and Find Full Text PDFBackground: Detailed understanding of the association between intraoperative left atrial and left ventricular diastolic function and postoperative atrial fibrillation is lacking. In this post hoc analysis of the Posterior Left Pericardiotomy for the Prevention of Atrial Fibrillation after Cardiac Surgery (PALACS) trial, we aimed to evaluate the association of intraoperative left atrial and left ventricular diastolic function as assessed by transesophageal echocardiography (TEE) with postoperative atrial fibrillation.
Methods: PALACS patients with available intraoperative TEE data (n = 402 of 420; 95.
Background: More than 90% of patients developing heart failure (HF) have an epidemiological background of hypertension. The most frequent concomitant conditions are type 2 diabetes mellitus, obesity, atrial fibrillation, and coronary disease, all disorders/diseases closely related to hypertension.
Methods: HF outcome research focuses on decreasing mortality and preventing hospitalization for worsening HF syndrome.
Article Synopsis
- - The study investigated sex differences in stroke risk among patients with atrial fibrillation (AF) who have hypertension and left ventricular hypertrophy (LVH), using data from a large clinical trial.
- - Among patients aged 55-63, males had a higher prevalence of both history and new-onset AF compared to females, but this gap narrowed with age.
- - The findings suggested that females with new-onset AF are at a greater stroke risk than males, particularly for those over 64 years, while the risk was similar for both sexes in patients with a history of AF.
Background: COVID-19 is associated with cardiac dysfunction. This study tested the relative prognostic role of left (LV), right and bi- (BiV) ventricular dysfunction on mortality in a large multicenter cohort of patients during and after acute COVID-19 hospitalization.
Methods/results: All hospitalized COVID-19 patients who underwent clinically indicated transthoracic echocardiography within 30 days of admission at four NYC hospitals between March 2020 and January 2021 were studied.
Aims: Chimeric antigen receptor T-cell therapy (CAR-T) harnesses a patient's immune system to target cancer. There are sparse existing data characterizing death outcomes after CAR-T-related cardiotoxicity. This study examines the association between CAR-T-related severe cardiovascular events (SCE) and mortality.
View Article and Find Full Text PDFBackground: In the Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery (PALACS) trial, posterior pericardiotomy was associated with a significant reduction in postoperative atrial fibrillation (POAF) after cardiac surgery. We aimed to investigate the mechanisms underlying this effect.
Methods: We included PALACS patients with available echocardiographic data (n = 387/420, 92%).
Aims: Atrial fibrillation (AF) and heart failure (HF) often coexist. However, whether AF onset before HF or vice versa is associated with the worst outcome remains unclear. A consensus of large studies can guide future research and preventive strategies to better target high-risk patients.
View Article and Find Full Text PDFBackground: Functional mitral regurgitation (FMR) is a known risk factor for right ventricular dysfunction (RV). RV global longitudinal strain (GLS) is an emerging index of RV function; however, the magnitude of agreement between RV GLS by echocardiography (echo) and cardiac magnetic resonance (CMR) and the relative utility of each modality for both the diagnosis of RV and prognostication of all-cause mortality and heart failure hospitalization remain unknown.
Results: 32% of patients had RV (EF < 50%) on CMR, among whom there was more advanced NYHA class and lower LV and RV ejection fraction (all p < 0.
Background: Left ventricular (LV) ischemia has been variably associated with functional mitral regurgitation (FMR). Determinants of FMR in patients with ischemia are poorly understood.
Objectives: This study sought to test whether contractile mechanics in ischemic myocardium underlying the mitral valve have an impact on likelihood of FMR.
Background And Aims: Rates of cardiovascular disease (CVD) among American Indians (AI) have been increasing. Although we have observed an association between atherosclerosis and CVD in older adults, the potential association among young AI is unclear. Therefore, we aim to describe the prevalence of atherosclerosis among young AI and determine its association with CVD and all-cause mortality.
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