Publications by authors named "Richard Alan Cohen"
Significance: Oxidative post-translational modifications (OPTMs) have been demonstrated as contributing to cardiovascular physiology and pathophysiology. These modifications have been identified using antibodies as well as advanced proteomic methods, and the functional importance of each is beginning to be understood using transgenic and gene deletion animal models. Given that OPTMs are involved in cardiovascular pathology, the use of these modifications as biomarkers and predictors of disease has significant therapeutic potential.
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- Reactive oxygen and nitrogen species are important for both keeping our body systems in balance and causing heart diseases like atherosclerosis and hypertension.
- Special amino acids called methionine and cysteine help regulate how cells work by undergoing changes that affect protein function.
- Future research aims to create new medicines that can specifically target parts of cells to control certain processes related to heart health.