Publications by authors named "Richard A Stewart"
Article Synopsis
- The Wnt/β-catenin signaling pathway is crucial for animal development and maintaining stem cells, depending on the nuclear presence of β-catenin as a transcriptional co-activator.
- β-catenin forms phase-separated biomolecular condensates (BMCs) that are essential for gene regulation and interaction with TCF/LEF family transcription factors.
- Research shows that specific aromatic amino acids in β-catenin's disordered regions are necessary for BMC formation and effective Wnt target gene activation, with mutations affecting signaling without altering nuclear transport.
