Publications by authors named "Richard A Sims"
Importance: Patients with early-onset atrial fibrillation (AF) are enriched for rare variants in cardiomyopathy and arrhythmia genes. The clinical significance of these rare variants in patients with early-onset AF is unknown.
Objective: To assess the association between rare variants in cardiomyopathy and arrhythmia genes detected in patients with early-onset AF and time to death.
We describe a case of myocarditis associated with a brown recluse spider bite in a 31-year-old man. Cardiac magnetic resonance revealed late gadolinium enhancement in the lateral wall and inferior wall. There was also regional elevation of the myocardial T2 and extracellular volume indicative of myocardial edema.
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- Early-onset atrial fibrillation (AF) may indicate serious inherited heart conditions, prompting a study on genetic testing for these cases.
- Researchers conducted a study involving participants diagnosed with AF before age 66, analyzing their genomes to find rare genetic variants linked to heart disease.
- Out of 1,293 participants, about 10.1% had identified disease-associated variants, while many others had variants of unclear significance or no concerning variants at all.